Evidence map›Paper›PMID 42190872›Full record

Trial reportMetabolism: clinical and experimental2026

Constant-routine protocol reveals an endogenous circadian rhythm in diet-induced thermogenesis with a peak in the biological morning.

Nina Vujović, Han-Chow E Koh, Su Wei Heng, Priyanka Panjwani, Charlotte Van Zee, Wei Wang, Jingyi Qian, Marta Garaulet, Frank A J L Scheer

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Metabolism: clinical and experimental, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nina VujovićMedical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA.
Han-Chow E KohMedical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA. Electronic address: hkoh@bwh.harvard.edu.
Su Wei HengMedical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA.
Priyanka PanjwaniMedical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA.
Charlotte Van ZeeMedical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA.
Wei WangMedical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA.
Jingyi QianMedical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA.
Marta GarauletDepartment of Physiology, Regional Campus of International Excellence, University of Murcia, Murcia, Spain; Biomedical Research Institute of Murcia, IMIB-Arrixaca-UMU, University Clinical Hospital, Murcia, Spain.
Frank A J L ScheerMedical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA. Electronic address: fscheer@mgb.org.

Funding

Effect of high fat diet on the circadian system and on circadian rhythms in energy intake and expenditureR01HL167746 · BRIGHAM AND WOMEN'S HOSPITAL · 2025 to 2025
$806k
Effect of temporal distribution of macronutrient intake on metabolismR01HL164454 · BRIGHAM AND WOMEN'S HOSPITAL · 2025 to 2025
$805k
Food Timing to Mitigate Adverse Consequences of Night WorkR01HL153969 · BRIGHAM AND WOMEN'S HOSPITAL · 2025 to 2025
$758k
NHLBI NIH HHS K99 HL148500NHLBI NIH HHS R01 HL153969NHLBI NIH HHS R01 HL164454NHLBI NIH HHS R01 HL167746NIDDK NIH HHS R01 DK099512NIDDK NIH HHS R01 DK102696
6 · The paper itself

Abstract

Late meal timing has been linked to increased body mass, although the physiological mechanisms are unknown. While previous research has suggested that identical meals consumed in the morning produce greater thermogenic responses than evening meals, it is unclear whether this is due to endogenous circadian control or due to behavioral and environmental factors. Therefore, this mechanistic randomized trial tested whether the endogenous circadian system, thus independently of sleep/wake, rest/activity, body posture, dark/light, and fasting/eating cycles, modulates diet-induced thermogenesis (DIT). To unmask endogenous circadian effects from environmental and behavioral confounds, 16 healthy adults with overweight or obesity (12 males; mean ± SD age, 36 ± 11 years; BMI, 28.8 ± 2.4 kg·m

Indexed as

Circadian RhythmDietThermogenesisAdultEnergy MetabolismFastingFemaleHumansMaleMealsMiddle AgedObesityOverweightSleepCircadian rhythmConstant routine protocolEnergy expenditureThermic effect of food

Identifiers

PMID42190872
PMCPMC13292443

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.