Trial reportEuropean journal of applied physiology2026
Effects of high-intensity and blood-flow-restricted resistance training on tendon adaptations in older men.
Trial report in European journal of applied physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05744167 (Resistance Training and Muscle - Brain Crosstalk), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Resistance Training and Muscle - Brain Crosstalk
Who cites it
1 citing paper in PubMed.
- Comparing high-intensity resistance training incorporating periodic eccentric-only exercise with blood flow restriction training in older men: physiological responses and exercise feasibility.European journal of applied physiology · 2026Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study investigated the effects of combined concentric-eccentric high-intensity resistance training (HIRT) and low-load blood flow restriction training (BFRT) on tendon properties and function in older men.
methodsThis parallel three-group controlled trial with constrained allocation included two exercise interventions (i.e., HIRT and BFRT) and a non-exercise control (CON). Participants in the exercise groups trained twice weekly for 12 weeks, and the total relative training volume was matched between groups. Assessments before and after the intervention included patellar tendon stiffness as the primary outcome, followed by tendon morpho-mechanical characteristics (cross-sectional area and tangent modulus) and knee extensor strength.
resultsLeg extension one-repetition maximum (1RM) increased in both HIRT (+ 40.4%, p < 0.001) and BFRT (+ 18.1%, p < 0.01) but not in CON (p > 0.05). HIRT significantly increased PT stiffness (+ 5.5%, p = 0.034) but not BFRT (PT stiffness: - 4.1%); the presence of divergent outcomes was supported by a significant time × intervention interaction (p < 0.05). PT cross-sectional area (CSA) increased in both training groups compared with CON (+ 4.3% in HIRT, + 3.6% in BFRT; both p < 0.001) but did not differ between HIRT and BFRT (p > 0.05). Changes in muscle strength correlated positively with tendon adaptations: the change (Δ) in 1RM correlated with Δstiffness (r = 0.35, p = 0.034) and ΔPTCSA (r = 0.45, p = 0.004).
conclusionThese findings suggest that HIRT may be more effective than BFRT for improving tendon mechanical function in older adults, whereas BFRT appears to preferentially affect tendon morphology rather than material properties over 12 weeks. CLINICALTRIALS: gov Identifier: NCT05744167.
Indexed as
Identifiers
42191902What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.