ReviewJournal of cardiovascular translational research2026
Psychological Scars and Physical Consequences: Linking PTSD to Cardiovascular Health.
Review in Journal of cardiovascular translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
3 authors.
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Abstract
Post traumatic stress disorder (PTSD) is defined as a mental health condition that occurs after experiencing a traumatic event. Patients diagnosed with PTSD have a 30-45% increase in cardiovascular disease (CVD) risk or cardiac-specific mortality even after adjusting for depression, demographic, clinical (e.g., age, blood pressure, body mass index (BMI), and tobacco use), and psychosocial factors. With this, the lifetime prevalence of PTSD has a notable sex disparity: women have a prevalence of approximately 10%, compared to 4% in men. Mechanisms explaining the increased risk of CVD in PTSD patients is unclear, leaving this patient population vulnerable as well as placing a substantial economic burden on the United States healthcare system. In this review, we will discuss the effect of PTSD on cardiovascular physiology, with an emphasis on sex differences, mechanisms of inflammation, and impaired ANS responses. In addition, we will summarize current and experimental therapeutics for PTSD that may help mitigate the risk of CVD.
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