Evidence map›Paper›PMID 42192040›Full record

ArticleAntonie van Leeuwenhoek2026

Integrated bioactivity assessment of the cyanobacterium plectonema terebrans extract: an in vitro and in silico study.

Sanjana Sabat, Sagar Patra, Chandra Sourav, Pokhrel Ankit, Mohd Shahnawaz Khan, Bigyan Ranjan Jali, Ajit Kumar Bishoyi, Rabindra Nath Padhy

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In one paragraph

Article in Antonie van Leeuwenhoek, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sanjana SabatCentral Research Laboratory, Institute of Medical Sciences and Sum Hospital, Siksha 'O' Anusandhan Deemed to Be University, Bhubaneswar, Odisha, 751003, India.
Sagar PatraCentral Research Laboratory, Institute of Medical Sciences and Sum Hospital, Siksha 'O' Anusandhan Deemed to Be University, Bhubaneswar, Odisha, 751003, India.
Chandra SouravDepartment of Electronics and Information Engineering, Jeonbuk National University, Jeonju, 54896, South Korea.
Pokhrel AnkitDepartment of Electronics and Information Engineering, Jeonbuk National University, Jeonju, 54896, South Korea.
Mohd Shahnawaz KhanDepartment of Biochemistry, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia.
Bigyan Ranjan JaliDepartment of Chemistry, Veer Surendra Sai University of Technology Burla Sambalpur Odisha, Odisha, 768018, India.
Ajit Kumar BishoyiCentral Research Laboratory, Institute of Medical Sciences and Sum Hospital, Siksha 'O' Anusandhan Deemed to Be University, Bhubaneswar, Odisha, 751003, India. Bishoyiajit96@gmail.com.ORCID http://orcid.org/0000-0002-7739-5616
Rabindra Nath PadhyCentral Research Laboratory, Institute of Medical Sciences and Sum Hospital, Siksha 'O' Anusandhan Deemed to Be University, Bhubaneswar, Odisha, 751003, India. rnpadhy54@gmail.com.ORCID http://orcid.org/0000-0002-2522-9843

Funding

King Saud University, Riyadh, Saudi Arabia ORF-2025-352SOA 24R9116A02
6 · The paper itself

Abstract

This study investigated the antimicrobial potential of the cyanobacterium Plectonema terebrans using integrated in vitro and in silico methods. Chemical profiling via FTIR, LC-MS, and GC-MS analyses suggested the presence of various classes of metabolites, including alkaloids, phenolics, and esters. The butanol extract exhibited significant antibacterial activity against Streptococcus pyogenes with 23 mm ZOI, while the ethyl acetate extract demonstrated potent antifungal efficacy against Trichophyton rubrum with MIC 0.19 mg/mL. Computational analysis detected metabolite Ethyl [5-hydroxy-1-(6-methoxy-4-methyl-3-quinolinyl)-3-methyl-1H-pyrazol-4-yl] acetate as a promising candidate, showing a binding energy of - 7.597 kcal/mol against the 1AJ0 target. Furthermore, 100 ns molecular dynamics simulations confirmed the stability of this complex, highlighting P. terebrans as a promising source for novel drug development.

Indexed as

Anti-Bacterial AgentsAntifungal AgentsCyanobacteriaArthrodermataceaeComputer SimulationMicrobial Sensitivity TestsMolecular Docking SimulationMolecular Dynamics SimulationStreptococcus pyogenesAnti-Bacterial AgentsAntifungal AgentsAntimicrobial activityBioactive secondary metabolitesMolecular dockingPlectonema terebrans

Identifiers

PMID42192040

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.