Quorum Sensing and Quorum Quenching in Pseudomonas aeruginosa and Staphylococcus aureus Infections: Therapeutic Potential, Limitations and Clinical Challenges.

Emilia Nowak, Matylda Korgiel, Karolina Pawłuszkiewicz, Jarosław Widelski, Bachar Cheaib, Emil Paluch

Abstract readReview

In one paragraph

Review in Antibiotics (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Next-generation anti-infective drugs in the post-antibiotic era: focusing on anti-virulence agents targeting the bacterial quorum sensing system.Frontiers in cellular and infection microbiology · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Emilia NowakBillennium Spółka Akcyjna, Tadeusza Czackiego 15/17, 00-043 Warsaw, Poland.ORCID 0009-0002-3412-0142

Matylda KorgielFaculty of Medicine, Wroclaw Medical University, 50-376 Wroclaw, Poland.ORCID 0009-0009-8265-406X

Karolina PawłuszkiewiczFaculty of Medicine, Wroclaw Medical University, 50-376 Wroclaw, Poland.ORCID 0009-0006-1297-5958

Jarosław WidelskiDepartment of Pharmacognosy with Medicinal Plants Garden, Lublin Medical University, 20-093 Lublin, Poland.ORCID 0000-0003-3154-9138

Bachar CheaibGerman Center for Lung Research (DZL), Translational Lung Research Center Heidelberg (TLRC), Department of Infectious Diseases, Medical Microbiology and Hygiene, Medical Faculty Heidelberg University, Im Neuenheimer Feld 672, 69120 Heidelberg, Germany.

Emil PaluchDepartment of Microbiology, Faculty of Medicine, Wroclaw Medical University, Tytusa Chalubinskiego 4, 50-376 Wroclaw, Poland.ORCID 0000-0002-3549-6136

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial resistance (AMR) represents a major global health threat, largely driven by antibiotic overuse and the protective role of bacterial biofilms. Quorum sensing (QS), a bacterial communication system regulating virulence and biofilm formation, has emerged as a promising therapeutic target. Quorum quenching (QQ), which disrupts QS without directly inhibiting bacterial growth, is considered a potential anti-virulence strategy that may reduce selective pressure for resistance. This review critically evaluates recent advances in QQ research, focusing on its clinical applicability, limitations, and risks. We analyzed studies from the last five years involving natural compounds, synthetic molecules, nanoparticles (NPs), and combination therapies targeting key pathogens such as

Indexed as

anti-virulence therapybiofilmsdrug resistancemicrobialPseudomonas aeruginosaQuorum quenchingQuorum sensingStaphylococcus aureus

Identifiers

PMID42192669

DOI10.3390/antibiotics15050447

PMCPMC13203571

What Socratic holds

Textmetadata

LicenceCC BY

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.