Evidence map›Paper›PMID 42193108›Full record

ArticleCurrent issues in molecular biology2026

Phytochemical Analysis, GC-MS Chemical Profiling, and In Vitro Antidiabetic Evaluation of South African

Buang Matseke, Daniel Tswaledi, Kokoette Bassey

Abstract read
In one paragraph

Article in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Buang MatsekeDepartment of Pharmaceutical Sciences, School of Pharmacy, Sefako Makgatho Health Sciences University, Ga-Rankuwa, Pretoria 0204, South Africa.ORCID 0000-0003-3915-160X
Daniel TswalediDepartment of Biochemistry and Biotechnology, School of Science and Technology, Sefako Makgatho Health Sciences University, Ga-Rankuwa, Pretoria 0204, South Africa.ORCID 0000-0002-9960-5565
Kokoette BasseyDepartment of Pharmaceutical Sciences, School of Pharmacy, Sefako Makgatho Health Sciences University, Ga-Rankuwa, Pretoria 0204, South Africa.ORCID 0000-0001-8178-1221

Funding

National Research Foundation MND210801627954
6 · The paper itself

Abstract

background

methodsLeaves were sequentially extracted using solvents of increasing polarity. Phytochemical composition was determined using standard colorimetric assays, while gas chromatography-mass spectrometry (GC-MS) was employed for compound identification. Antioxidant activity was evaluated using dot blot, DPPH radical scavenging, hydrogen peroxide scavenging, and ferric reducing power assays. Antidiabetic potential was assessed using α-amylase, α-glucosidase, and β-glucosidase inhibitory assays, with acarbose as the reference drug. Cytotoxicity was determined by using the MTT assay on Vero and HEK-293 cell lines.

resultsPhytochemical screening revealed alkaloids, flavonoids, terpenoids, saponins, glycosides, and steroids. GC-MS analysis identified compounds associated with antidiabetic activity, including vanillin, 2,4-di-tert-butylphenol, oleic acid, phytol, and hexadecenoic acid. All extracts exhibited antioxidant activity, with the ethyl acetate extract showing the strongest effect. Enzyme inhibition was concentration dependent. The dichloromethane and ethyl acetate extracts showed stronger α-amylase inhibition (IC

conclusionsThese findings support the traditional use of

Indexed as

bioactive compoundscytotoxicitydiabetes mellitusenzyme inhibitionMomordica balsaminaoxidative stress

Identifiers

PMID42193108
PMCPMC13204824

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.