Association of Vitamin D Receptor Gene Polymorphisms and Hypovitaminosis D with Reduced Bone Mineral Density in Survivors of Childhood Leukemia: A Study in Algerian Patients.

Wafa Khelaifia, Ines Gouaref, Fatma Zohra Djaballah-Ider, Nabila Bouterfas, Chafia Touil-Boukoffa, Assia Galleze

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Article in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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Authors and funding

6 authors.

Wafa KhelaifiaCytokines and Nitric Oxide Synthases Team, Cellular and Molecular Biology Laboratory, Faculty of Biological Sciences, Houari Boumediene University of Sciences and Technology, Algiers 16111, Algeria.ORCID 0000-0003-4991-0120

Ines GouarefBioenergetics and Intermediary Metabolism Team, Department of Biology and Organism Physiology, Faculty of Biological Sciences, Houari Boumediene University of Sciences and Technology, Algiers 16111, Algeria.

Fatma Zohra Djaballah-IderCytokines and Nitric Oxide Synthases Team, Cellular and Molecular Biology Laboratory, Faculty of Biological Sciences, Houari Boumediene University of Sciences and Technology, Algiers 16111, Algeria.

Nabila BouterfasPediatric Department, Beni Messous University Hospital, Algiers 16206, Algeria.

Chafia Touil-BoukoffaCytokines and Nitric Oxide Synthases Team, Cellular and Molecular Biology Laboratory, Faculty of Biological Sciences, Houari Boumediene University of Sciences and Technology, Algiers 16111, Algeria.

Assia GallezeCytokines and Nitric Oxide Synthases Team, Cellular and Molecular Biology Laboratory, Faculty of Biological Sciences, Houari Boumediene University of Sciences and Technology, Algiers 16111, Algeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Survivors of childhood leukemia are at increased risk of long-term skeletal complications, including reduced bone mineral density (BMD). Vitamin D deficiency and genetic variations in the vitamin D receptor (VDR) gene are important factors influencing bone health, yet their combined effects remain insufficiently studied, particularly in North African populations. This case-control study included 130 survivors of childhood acute lymphoblastic leukemia (ALL) in remission (age range: 5-26 years) and 110 age- and sex-matched healthy controls recruited from Beni Messous Hospital. BMD was assessed at the lumbar spine and femoral neck using dual-energy X-ray absorptiometry and expressed as z-scores. Serum 25-hydroxyvitamin D levels were measured, and VDR polymorphisms (FokI, ApaI, and BsmI) were analyzed using PCR-RFLP. Hypovitaminosis D was observed in 43.85% of patients at diagnosis and 23.07% after remission. Survivors had significantly lower BMD compared with controls at both the lumbar spine (z-score: -4.26 ± 0.75 vs. 0 ± 1,

Indexed as

bone mineral densityhypovitaminosis DPCR-RFLPsurvivors of childhood leukemiaVDR polymorphisms

Identifiers

PMID42193110

DOI10.3390/cimb48050506

PMCPMC13206659

What Socratic holds

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