Evidence mapPaperPMID 42193227Full record

ArticleAntioxidants (Basel, Switzerland)2026

YAK577 Attenuates Vascular Calcification by Targeting an MMP14-NOX2/ROS Axis in VSMCs and a Vitamin D

Hongyan Zhou, Hae Jin Kee, Seong Min Jeong, Liyan Bai, Le Wan, Seong Hoon Kim, Seung Hun Lee, Thomas Kurz, Doo Sun Sim, Myung Ho Jeong and 1 more

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hongyan ZhouHeart Research Center, Chonnam National University Hospital, Gwangju 61469, Republic of Korea.ORCID 0009-0002-3244-5840
Hae Jin KeeHeart Research Center, Chonnam National University Hospital, Gwangju 61469, Republic of Korea.ORCID 0000-0002-9774-4828
Seong Min JeongHeart Research Center, Chonnam National University Hospital, Gwangju 61469, Republic of Korea.
Liyan BaiEmergency Critical Center, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
Le WanDepartment of Orthopedics, Chonnam National University Hospital, Gwangju 61469, Republic of Korea.ORCID 0009-0000-1303-1875
Seong Hoon KimDepartment of Cardiology, Chonnam National University Medical School, Gwangju 61469, Republic of Korea.ORCID 0000-0002-2533-8441
Seung Hun LeeDepartment of Cardiology, Chonnam National University Medical School, Gwangju 61469, Republic of Korea.ORCID 0000-0002-2337-7826
Thomas KurzInstitute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstrβe 1, 40225 Düsseldorf, Germany.ORCID 0000-0002-9474-4224
Doo Sun SimDepartment of Cardiology, Chonnam National University Medical School, Gwangju 61469, Republic of Korea.ORCID 0000-0003-4162-7902
Myung Ho JeongGwangju Veterans Hospital, Gwangju 62284, Republic of Korea.ORCID 0000-0003-2424-810X
Young Joon HongDepartment of Cardiology, Chonnam National University Medical School, Gwangju 61469, Republic of Korea.ORCID 0000-0003-0192-8161

Funding

Ministry of Health & Welfare RS-2023-00302146 and RS-2023-00302153National Research Foundation of Korea RS-2022-NR069133 and RS-2025-24536036
6 · The paper itself

Abstract

Vascular calcification is an actively regulated process driven by vascular smooth muscle cell (VSMC) osteogenic reprogramming and promoted by oxidative stress and extracellular matrix remodeling. We investigated whether the novel histone deacetylase inhibitor YAK577 mitigates calcification by modulating an MMP14-NOX2/ROS-associated pathway in calcification medium (CM)-treated VSMCs and a vitamin D

Indexed as

histone deacetylase inhibitorMMP14NOX2NOX2-derived ROSosteogenic transdifferentiationvascular calcificationvascular smooth muscle cellsvitamin D3-induced vascular calcificationYAK577

Identifiers

PMID42193227
PMCPMC13203591

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.