ArticleAntioxidants (Basel, Switzerland)2026
Modulatory Effects of Antioxidant Supplementation on Serum Oxidative Stress Biomarkers MDA and T-AOC in Females with Unexplained Infertility.
Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Unexplained infertility (UI) continues to pose a diagnostic challenge, affecting a considerable proportion of reproductive-aged women. Increasing evidence suggests that oxidative stress (OS) may contribute to impaired female reproductive function. Malondialdehyde (MDA) is a lipid peroxidation marker, while total antioxidant capacity (T-AOC) reflects overall antioxidant defense. Evaluating these biomarkers may help to better understand the role of OS in UI and the potential benefit of antioxidant therapy. A prospective observational study included 30 women diagnosed with primary unexplained infertility. Serum levels of MDA and T-AOC were measured at baseline and after a period of antioxidant supplementation lasting 1-7 months (duration mode: 3 months). All participants received standardized antioxidant therapy consisting of vitamin E (50 mg/day), zinc (15 mg/day), coenzyme Q10 (15 mg/day), and selenium (70 µg/day). Participants with known causes of infertility were excluded. Nonparametric statistical tests were used to evaluate changes in oxidative stress markers before and after supplementation and to compare subgroups with and without comorbidities. Median baseline MDA concentration was 228.2 ng/mL and decreased significantly after antioxidant supplementation to 173.9 ng/mL (
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