Evidence map›Paper›PMID 42194502›Full record

ReviewHealthcare (Basel, Switzerland)2026

Periodontitis and Rheumatoid Arthritis: Shared Pathophysiology, Bidirectional Association, and Therapeutic Implications-A Narrative Review.

Neda Najafimakhsoos, Emanuela Pashollari, Nazzarena Malavolta, Francesca Zangari, Claudio Cesari

Abstract readReview
In one paragraph

Review in Healthcare (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Neda NajafimakhsoosDepartment of Biomedical and Neuromotor Sciences, University of Bologna, 40125 Bologna, Italy.ORCID 0009-0007-2376-7289
Emanuela PashollariDepartment of Dentistry, Vita-Salute San Raffaele University, 20132 Milan, Italy.
Nazzarena MalavoltaCasa di Cura Madre Fortunata Toniolo, 40141 Bologna, Italy.ORCID 0000-0002-6158-3671
Francesca ZangariDepartment of Dentistry, Vita-Salute San Raffaele University, 20132 Milan, Italy.ORCID 0000-0003-3830-4600
Claudio CesariPeriodontal Unit, Department of Dentistry, Vita-Salute San Raffaele University, 20132 Milan, Italy.ORCID 0000-0003-2876-6035

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Periodontitis (PD) and rheumatoid arthritis (RA) are chronic inflammatory disorders that impose substantial individual and societal burdens worldwide. PD is characterized by progressive destruction of the periodontal ligament and alveolar bone, leading to tooth loss, impaired oral function, and sustained systemic inflammatory burden. RA, affecting approximately 0.5-1% of the population, is a chronic autoimmune disease marked by persistent synovial inflammation, progressive joint destruction, disability, and reduced quality of life. Increasing evidence indicates that these conditions are biologically and clinically interconnected. Both diseases share key pathogenic pathways, including microbial dysbiosis, immune dysregulation, chronic inflammation, genetic susceptibility, and aberrant autoantibody responses. Particular attention has focused on keystone periodontal pathogens such as

Indexed as

anti-citrullinated protein antibodiesautoimmunitybidirectional associationcitrullinationdisease-modifying antirheumatic drugsmicrobial dysbiosisoral microbiomeperiodontal therapyperiodontitisPorphyromonas gingivalisrheumatoid arthritissystemic inflammation

Identifiers

PMID42194502
PMCPMC13206173

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.