Elevated p-Cresyl Sulfate Levels Are Associated with Impaired Endothelial Function in Patients Undergoing Long-Term Peritoneal Dialysis.

I-Min Su, Bang-Gee Hsu, Chin-Hung Liu, Ho-Hsiang Chang, Ming-Chun Chen

Abstract read

In one paragraph

Article in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

I-Min SuDepartment of Anesthesiology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi 62247, Taiwan.ORCID 0000-0002-3021-0979

Bang-Gee HsuSchool of Medicine, Tzu Chi University, Hualien 97004, Taiwan.ORCID 0000-0001-9364-4558

Chin-Hung LiuGraduate Institute of Clinical Pharmacy, School of Medicine, Tzu Chi University, Hualien 97004, Taiwan.ORCID 0000-0002-8144-9146

Ho-Hsiang ChangDivision of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97004, Taiwan.

Ming-Chun ChenSchool of Medicine, Tzu Chi University, Hualien 97004, Taiwan.ORCID 0000-0003-0910-1185

Funding

Tzu Chi Foundation TCRD113-058 and TCMF-A111-02

6 · The paper itself

Abstract

p-Cresyl sulfate (PCS) is associated with endothelial injury and adverse cardiovascular outcomes. However, its association with endothelial function in patients on peritoneal dialysis (PD) remains unclear. In this cross-sectional study, 82 patients receiving PD were enrolled. Serum PCS concentrations were quantified using high-performance liquid chromatography-mass spectrometry. Endothelial function was evaluated by digital thermal monitoring (DTM), and vascular reactivity was stratified based on vascular reactivity index (VRI) values into good (>2.0), intermediate (1.0-1.9), and poor (<1.0). Overall, 46.3%, 43.9%, and 9.8% of participants had poor, intermediate, and good vascular reactivity, respectively. Poor reactivity was associated with a higher prevalence of diabetes (

Indexed as

endothelial functionp-Cresyl sulfateperitoneal dialysisvascular reactivity index

Identifiers

PMID42195343

DOI10.3390/life16050787

PMCPMC13208358

What Socratic holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.