ArticleLife (Basel, Switzerland)2026
Integrated Assessment of Inflammatory and Lipid-Metabolic Biomarkers in Psoriasis: Implications for Metabolic Syndrome.
Article in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
(1) Background: Psoriasis is increasingly recognized as a systemic inflammatory disease associated with metabolic comorbidities. However, the hierarchical relationship between inflammatory activation and insulin resistance in driving metabolic syndrome (MetS) remains incompletely defined. This study aimed to characterize the integrated inflammatory-metabolic architecture of psoriasis using multivariate and latent domain modeling. (2) Methods: In this cross-sectional hospital-based study (2020-2022), 235 adult patients with psoriasis were evaluated. Systemic inflammatory markers (NLR, SII, CRP, ESR) and composite metabolic indices (TyG, AIP, METS-IR) were assessed. Correlation analysis, multivariable linear and logistic regression, interaction modeling, and principal component analysis (PCA) were performed to examine independent associations and underlying domain structure. (3) Results: Inflammatory and metabolic markers showed modest but significant correlations. In multivariable logistic regression, the TyG index was the strongest independent predictor of MetS (OR = 5.15,
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