Evidence map›Paper›PMID 42196148›Full record

ArticleInternational journal of molecular sciences2026

Upregulation of a Circular

Vaia K Stafyla, Spyridon Christodoulou, Panagiotis Tsiakanikas, Nikolaos Michalopoulos, Nikolaos Danias, Panagiotis Kokoropoulos, Christos K Kontos, Nikolaos Arkadopoulos

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Vaia K StafylaFourth Department of Surgery, University General Hospital "Attikon", National and Kapodistrian University of Athens, 12462 Athens, Greece.
Spyridon ChristodoulouFourth Department of Surgery, University General Hospital "Attikon", National and Kapodistrian University of Athens, 12462 Athens, Greece.ORCID 0000-0002-4725-648X
Panagiotis TsiakanikasDepartment of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, Panepistimiopolis, 15771 Athens, Greece.ORCID 0000-0003-3920-2278
Nikolaos MichalopoulosFirst Department of Propaedeutic Surgery, "Hippokration" General Hospital of Athens, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Nikolaos DaniasFourth Department of Surgery, University General Hospital "Attikon", National and Kapodistrian University of Athens, 12462 Athens, Greece.
Panagiotis KokoropoulosFourth Department of Surgery, University General Hospital "Attikon", National and Kapodistrian University of Athens, 12462 Athens, Greece.ORCID 0000-0002-4267-6813
Christos K KontosDepartment of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, Panepistimiopolis, 15771 Athens, Greece.ORCID 0000-0002-9935-8461
Nikolaos ArkadopoulosFourth Department of Surgery, University General Hospital "Attikon", National and Kapodistrian University of Athens, 12462 Athens, Greece.ORCID 0000-0002-0355-0417

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, we have discovered several alternative circRNAs produced by alternative circularization of the primary transcripts of the apoptosis-related BAX gene. Among them, only three circRNAs, namely circ-BAX-6c, circ-BAX-18 and circ-BAX-74, are expressed in all studied triple-negative breast cancer (BrCa) cell lines and in the normal one; moreover, circ-BAX-18 is the only one comprising a novel microexon with canonical splice sites. Therefore, in this study, we examined circ-BAX-18 expression in BrCa tissues and its potential association with tumor features and patients' prognosis. For this purpose, tumor samples from a cohort of 144 female BrCa patients were used, along with paired non-cancerous breast tissue for 14 cases. circ-BAX-18 expression levels were quantified using an optimized,

Indexed as

bcl-2-Associated X ProteinBreast NeoplasmsRNA, CircularTriple Negative Breast NeoplasmsUp-RegulationAdultAgedBiomarkers, TumorFemaleGene Expression Regulation, NeoplasticHumansMiddle AgedPrognosisBAX protein, humanbcl-2-Associated X ProteinBiomarkers, TumorRNA, Circularbreast malignancycancer biomarkercircular RNA (circRNA)non-coding RNAprognostic biomarkertumor recurrence

Identifiers

PMID42196148
PMCPMC13206390

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.