Evidence map›Paper›PMID 42196162›Full record

ArticleInternational journal of molecular sciences2026

Digital PCR Quantification of a Circulating

Thais Biude Mendes, Indhira Dias Oliveira, Francine Tesser Gamba, Fernanda Teresa Lima, Bruna Fernanda Silva Cardoso Morales, Carla Renata Pacheco Donato Macedo, Luiz Fernando Teixeira, Silvia Regina Caminada de Toledo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Thais Biude MendesGenetics Laboratory, Pediatric Oncology Institute (IOP/GRAACC), Federal University of Sao Paulo, Sao Paulo 04039-001, SP, Brazil.ORCID 0000-0003-0114-4578
Indhira Dias OliveiraGenetics Laboratory, Pediatric Oncology Institute (IOP/GRAACC), Federal University of Sao Paulo, Sao Paulo 04039-001, SP, Brazil.
Francine Tesser GambaGenetics Laboratory, Pediatric Oncology Institute (IOP/GRAACC), Federal University of Sao Paulo, Sao Paulo 04039-001, SP, Brazil.ORCID 0000-0002-2959-8363
Fernanda Teresa LimaGenetics Laboratory, Pediatric Oncology Institute (IOP/GRAACC), Federal University of Sao Paulo, Sao Paulo 04039-001, SP, Brazil.
Bruna Fernanda Silva Cardoso MoralesInstitute of Pediatric Oncology (IOP/GRAACC), Sao Paulo 04023-062, SP, Brazil.
Carla Renata Pacheco Donato MacedoInstitute of Pediatric Oncology (IOP/GRAACC), Sao Paulo 04023-062, SP, Brazil.
Luiz Fernando TeixeiraInstitute of Pediatric Oncology (IOP/GRAACC), Sao Paulo 04023-062, SP, Brazil.
Silvia Regina Caminada de ToledoGenetics Laboratory, Pediatric Oncology Institute (IOP/GRAACC), Federal University of Sao Paulo, Sao Paulo 04039-001, SP, Brazil.

Funding

National Science and Technology Institute for Children's Cancer Biology and Pediatric Oncology - INCT BioOncoPed 406484/2022-8PRONON (Programa Nacional de Apoio à Atenção Oncológica 25000.019858/2018-14
6 · The paper itself

Abstract

Retinoblastoma (RB) is the most common intraocular malignancy of childhood, yet molecular assessment of disease dissemination and minimal residual disease (MRD) remains challenging due to the contraindication of intraocular biopsy. Here, we evaluate the feasibility of cell-free RNA (cfRNA)- and circulating tumor cell RNA (ctcRNA)-based liquid biopsy for the sensitive detection of disseminated retinoblastoma using digital PCR (dPCR) targeting the retina-specific markers

Indexed as

Cell-Free Nucleic AcidsHomeodomain ProteinsPolymerase Chain ReactionRetinal NeoplasmsRetinoblastomaRNA-Binding ProteinsBiomarkers, TumorChild, PreschoolFemaleHumansInfantLiquid BiopsyMaleNeoplasm, ResidualTrans-ActivatorsBiomarkers, TumorCell-Free Nucleic Acidscone rod homeobox proteinHomeodomain ProteinsRNA-Binding ProteinsTrans-ActivatorsCRXdigital PCRliquid biopsyRBP3retinoblastoma

Identifiers

PMID42196162
PMCPMC13206994

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.