Evidence map›Paper›PMID 42196172›Full record

ArticleInternational journal of molecular sciences2026

Dietary Fructose Alters Duodenal Mucin Glycosylation and Mucus Production in High-Fat Diet-Fed Mice.

Donatella Mentino, Alessia Provera, Cristina Vecchio, Alessandro Antonioli, Anteneh Nigussie Sheferaw, Nastasia Taldone, Rossella Vitale, Chiara Passamonti, Stefania Fensore, Flavia Prodam and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Donatella MentinoDepartment of Biosciences, Biotechnology and Environment, University of Bari Aldo Moro, 70125 Bari, Italy.ORCID 0000-0002-0680-5251
Alessia ProveraDepartment of Health Sciences, University of Piemonte Orientale, 28100 Novara, Italy.ORCID 0000-0002-7027-3886
Cristina VecchioDepartment of Health Sciences, University of Piemonte Orientale, 28100 Novara, Italy.
Alessandro AntonioliDepartment of Health Sciences, University of Piemonte Orientale, 28100 Novara, Italy.ORCID 0000-0003-0716-4422
Anteneh Nigussie SheferawDepartment of Health Sciences, University of Piemonte Orientale, 28100 Novara, Italy.ORCID 0009-0004-5299-1464
Nastasia TaldoneDepartment of Biosciences, Biotechnology and Environment, University of Bari Aldo Moro, 70125 Bari, Italy.
Rossella VitalePediatric Unit, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari Aldo Moro, Piazza G. Cesare 11, 70124 Bari, Italy.
Chiara PassamontiDepartment of Mathematics, University of Luxembourg, 4365 Luxembourg, Luxembourg.
Stefania FensoreDepartment of Socio-Economic, Managerial and Statistical Studies, University of Chieti-Pescara, 65129 Pescara, Italy.ORCID 0000-0002-5308-2586
Flavia ProdamDepartment of Health Sciences, University of Piemonte Orientale, 28100 Novara, Italy.ORCID 0000-0001-9660-5335
Salvatore SuttiDepartment of Health Sciences, University of Piemonte Orientale, 28100 Novara, Italy.ORCID 0000-0002-0192-8199
Maria MastrodonatoDepartment of Biosciences, Biotechnology and Environment, University of Bari Aldo Moro, 70125 Bari, Italy.ORCID 0000-0002-0799-8032
Maria Felicia FaienzaPediatric Unit, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari Aldo Moro, Piazza G. Cesare 11, 70124 Bari, Italy.ORCID 0000-0002-1899-8337

Funding

Fondazione Cariplo ECS00000036
6 · The paper itself

Abstract

Fructose, a key component of modern diets, is closely linked to the growing prevalence of pediatric obesity and metabolic alterations. Although numerous studies highlight its systemic consequences, including altered carbohydrate and lipid metabolism and increased cardiovascular risk, the direct impact of fructose, particularly its role in modulating mucin composition, a key determinant of the mucosal barrier, remains poorly explored. This study investigated whether fructose supplementation modifies high-fat diet (HFD)-induced changes in duodenal mucin production and whether these effects vary depending on age in animals. To this end, young and adult mice were fed a normal diet (ND), HFD, or an HFD supplemented with 30% fructose (

Indexed as

Diet, High-FatDuodenumFructoseMucinsMucusAnimalsBrunner GlandsGlycosylationGoblet CellsIntestinal MucosaMaleMiceMice, Inbred C57BLFructoseMucinsage-related intestinal changesfructosehigh-fat dietintestinal glycosylation patternslectins

Identifiers

PMID42196172
PMCPMC13207898

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.