ReviewInternational journal of molecular sciences2026
Multidimensional Regulatory Network and Spatiotemporal Specificity of FOXO Transcription Factors in Digestive System Tumors: Recent Advances.
Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Digestive system malignancies are a globally prevalent type of cancer that severely threatens human health. As pivotal intracellular transcriptional regulators, the forkhead box O (FOXO) protein family plays central roles in diverse physiological and pathological processes, including cell proliferation, apoptosis, and metabolism. Accumulating evidence has verified that FOXO factors exhibit dual functions as both tumor suppressors and oncoproteins. Notably, this functional duality displays a spatiotemporally specific switching pattern according to distinct stages of tumor progression and the physiological characteristics of different digestive system tumors, which poses substantial challenges for FOXO-targeted cancer therapy. Therefore, this review systematically summarizes the molecular mechanisms underlying the functional switching of FOXO in digestive system malignancies from the two dimensions of tumor progression stage and tumor-specific physiological properties, and elaborates the corresponding targeted therapeutic strategies. This work aims to provide a systematic theoretical reference for the precise intervention of digestive system tumors.
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