Establishment of an Autoimmune Premature Ovarian Insufficiency Mouse Model with Proteomic Analyses: An Exploratory Study.

Ying Tian, Jiaqi Zhou, Xinyi Pei, Feiran Liu, Feiyang Diao

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ying TianThe Center for Clinical Reproductive Medicine, State Key Laboratory of Reproductive Medicine and Offspring Health, The First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing 212028, China.

Jiaqi ZhouState Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing 211166, China.

Xinyi PeiState Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing 211166, China.

Feiran LiuThe Center for Clinical Reproductive Medicine, State Key Laboratory of Reproductive Medicine and Offspring Health, The First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing 212028, China.

Feiyang DiaoThe Center for Clinical Reproductive Medicine, State Key Laboratory of Reproductive Medicine and Offspring Health, The First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing 212028, China.

Funding

National Key Research and Development Program 2022YFC2702505

6 · The paper itself

Abstract

Premature ovarian insufficiency (POI) impairs fertility and health in reproductive-age women, with autoimmune factors contributing to 4-30% of cases. To investigate immune dysregulation in POI, we developed two mouse models using pZP3 induction: regular immune (RE-POI) and enhanced immune (EN-POI) cycles. The EN-POI model exhibited stable, irreversible ovarian dysfunction, including disrupted estrous cycles, hormonal changes (elevated FSH, decreased AMH, and estradiol), follicular depletion, and infertility. Immune profiling demonstrated consistent T-lymphocyte imbalance across both RE-POI and EN-POI model groups, characterized by expanded splenic CD4

Indexed as

Autoimmune DiseasesPrimary Ovarian InsufficiencyProteomeProteomicsAnimalsCytokinesDisease Models, AnimalEstrous CycleFemaleMiceOvaryCytokinesProteomeautoimmunityimmune imbalancemouse modelpremature ovarian failureproteomics

Identifiers

PMID42196258

DOI10.3390/ijms27104270

PMCPMC13207734

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.