Evidence map›Paper›PMID 42196384›Full record

Trial reportInternational journal of molecular sciences2026

Exploratory Effects of a Novel Nutraceutical on Senescence-Related Protein Biomarkers in Healthy Adults: A Pilot Proteomics Study.

Sarah A Blomquist, Gregory Kelly, Christopher R D'Adamo, Chang Han, Haleigh Parker, Sara Adães, Colin R Gardner, Abhimanyu Ardagh, Shawn Ramer, William Scuba

Registry-linked trialAbstract readClinical Trial
In one paragraph

Trial report in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06953518 (An Open-Label Pilot Study of Qualia Senolytic Supplementation for the Attenuation of Systemic Inflammatory Cytokines), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06953518 nanot yet recruitingnot on this map

An Open-Label Pilot Study of Qualia Senolytic Supplementation for the Attenuation of Systemic Inflammatory Cytokines

TypeinterventionalSponsorQualia Life SciencesRan2025 to 2025Enrolled40ConditionsInflammationArmsQualia Senolytic
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sarah A BlomquistResearch and Development, Qualia Life Sciences, Carlsbad, CA 92008, USA.ORCID 0000-0002-1833-5701
Gregory KellyResearch and Development, Qualia Life Sciences, Carlsbad, CA 92008, USA.
Christopher R D'AdamoOvationLab, Richmond, VA 23220, USA.ORCID 0000-0002-2415-8158
Chang HanLuminoDx Inc., San Diego, CA 92121, USA.
Haleigh ParkerLuminoDx Inc., San Diego, CA 92121, USA.
Sara AdãesResearch and Development, Qualia Life Sciences, Carlsbad, CA 92008, USA.
Colin R GardnerResearch and Development, Qualia Life Sciences, Carlsbad, CA 92008, USA.
Abhimanyu ArdaghResearch and Development, Qualia Life Sciences, Carlsbad, CA 92008, USA.
Shawn RamerResearch and Development, Qualia Life Sciences, Carlsbad, CA 92008, USA.
William ScubaResearch and Development, Qualia Life Sciences, Carlsbad, CA 92008, USA.

Funding

Qualia Life Sciences N/A
6 · The paper itself

Abstract

Cellular senescence drives aging and age-related disease through the accumulation of senescent cells and their senescence-associated secretory phenotype (SASP). Emerging evidence suggests intermittent ("hit-and-run") senolytic interventions may improve healthspan by reducing senescent cell accumulation and the SASP. Healthy adults aged 45-79 were recruited for a decentralized, single-arm pilot study (NCT06953518) evaluating 2 days of nutraceutical supplementation (Qualia Senolytic). Fingerstick blood samples and validated quality of life (QoL) questionnaire data were collected on days 0 and 7. Primary outcomes were SASP biomarkers measured by the Olink

Indexed as

BiomarkersCellular SenescenceDietary SupplementsProteomicsSenescence-Associated Secretory PhenotypeAgedAgingCytokinesFemaleHumansMaleMiddle AgedPilot ProjectsQuality of LifeBiomarkersCytokinesagingcellular senescencedietary supplementhealthspanlongevitySASPsenolytic

Identifiers

PMID42196384
PMCPMC13207486

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.