ArticleInternational journal of molecular sciences2026
Efavirenz-Altered Gut-Microbiota,
Sandra Angélica Rojas-Osornio, Vladimir Paredes-Cervantes, María Magdalena Aguirre-García, Minerva Crespo-Ramírez, Claudia C Márquez-Mota, Raquel Aguilar-Rosales, José Moisés Talamantes-Gómez, Alma Reyna Escalona-Montaño, Águeda García-Pérez, Miguel Pérez de la Mora and 6 more
Abstract read
In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
16 authors.
Sandra Angélica Rojas-OsornioAcademia de Bioquímica Médica II, Departamento de Formación Básica Disciplinaria, Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City 11340, Mexico.ORCID 0000-0003-1525-8496 Vladimir Paredes-CervantesLaboratorio Central, Hospital de Especialidades "Dr. Antonio Fraga Mouret", Centro Médico Nacional "LaRaza", Instituto Mexicano del Seguro Social, Mexico City 02990, Mexico.ORCID 0000-0002-5327-1643 María Magdalena Aguirre-GarcíaUnidad de Investigación UNAM-INC, División de Investigación, Facultad de Medicina, Instituto Nacional de Cardiología Ignacio Chávez, Universidad Nacional Autónoma de México, Mexico City 14080, Mexico.ORCID 0000-0001-8696-9995 Minerva Crespo-RamírezDivision de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico.
Claudia C Márquez-MotaDepartamento de Nutrición Animal y Bioquímica, Facultad de Medicina Veterinaria y Zootécnia, Universidad Nacional Autónoma de México, Mexico City 02990, Mexico.ORCID 0000-0002-4311-381X Raquel Aguilar-RosalesUnidad de Investigación UNAM-INC, División de Investigación, Facultad de Medicina, Instituto Nacional de Cardiología Ignacio Chávez, Universidad Nacional Autónoma de México, Mexico City 14080, Mexico.ORCID 0009-0007-8236-2986 José Moisés Talamantes-GómezDepartamento de Nutrición Animal y Bioquímica, Facultad de Medicina Veterinaria y Zootécnia, Universidad Nacional Autónoma de México, Mexico City 02990, Mexico.
Alma Reyna Escalona-MontañoUnidad de Investigación UNAM-INC, División de Investigación, Facultad de Medicina, Instituto Nacional de Cardiología Ignacio Chávez, Universidad Nacional Autónoma de México, Mexico City 14080, Mexico.ORCID 0000-0002-0060-2939 Águeda García-PérezDepartamento de Nutrición Animal y Bioquímica, Facultad de Medicina Veterinaria y Zootécnia, Universidad Nacional Autónoma de México, Mexico City 02990, Mexico.
Miguel Pérez de la MoraDivision de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico.ORCID 0000-0003-1520-4439 Dasiel O Borroto-EscuelaReceptomics and Signaling Networks in Brain Diseases (Group C22), Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND., 29010 Malaga, Spain.ORCID 0000-0002-5736-373X Leticia Manuel-ApolinarUnidad de Investigación Médica en Enfermedades Endocrinas, Hospital de Especialidades, Centro Médico Nacional "Siglo XXI", Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico.
Gilberto Pérez-SánchezLaboratorio de Psicoinmunología, Dirección de Investigaciones Biomédicas en Salud Mental, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City 14370, Mexico.ORCID 0000-0003-3878-0631 Salvador Vazquez-VegaUnidad de Investigación Epidemiológica y en Servicios de Salud, Centro Médico Nacional "Siglo XXI", Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico.
Ricardo Martínez-LaraUnidad de Investigación Biomédica en Inmunología e Infectología, del Hospital de Infectología del Centro Médico Nacional "La Raza" IMSS, Mexico City 02990, Mexico.ORCID 0009-0008-0346-1327 Emiliano Tesoro-CruzUnidad de Investigación Biomédica en Inmunología e Infectología, del Hospital de Infectología del Centro Médico Nacional "La Raza" IMSS, Mexico City 02990, Mexico.ORCID 0000-0001-8877-8439 Funding
Mexican Social Security Institute FIS/IMSS/R-2021-785-057Universidad Nacional Autónoma de México IN210024
6 · The paper itselfAbstract
The gut microbiota produces molecules that trigger responses at the local and distant levels. It affects the brain through several metabolic products, including serotonin (5-HT). Tryptophan hydroxylase type 1 (Tph1) is the rate-limiting enzyme during 5-HT biosynthesis in the gut. Efavirenz (EFV), an antiretroviral agent against HIV, is associated with depression disorders and Tryptophan hydroxylase type 2 (
Indexed as
BenzoxazinesDepressionGastrointestinal MicrobiomeSerotoninTryptophan HydroxylaseAlkynesAnimalsCyclopropanesFatty Acids, VolatileMaleMiceAlkynesBenzoxazinesCyclopropanesefavirenzFatty Acids, VolatileSerotoninTph1 protein, mouseTryptophan Hydroxylasedepressionefavirenzgut microbiotaserotoninshort chain fatty acidstryptophan hydroxylase type 1
Identifiers
PMID42196482
PMCPMC13207138
What Socratic holds
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LicenceCC BY
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