A Signaling-Threshold Framework for Human Tooth Agenesis: Integrating Molecular Genetics with Developmental Field Theory.

Anna Ewa Kuc, Paulina Kuc, Natalia Kuc, Magdalena Sulewska, Marzena Tylicka, Michał Sarul

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In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anna Ewa KucDepartment of Dentofacial Orthopedics and Orthodontics, Wroclaw Medical University, 50-425 Wroclaw, Poland.ORCID 0000-0002-5281-0940

Paulina KucFaculty of Medicine, Medical University of Bialystok, ul. Kilińskiego 1, 15-089 Bialystok, Poland.

Natalia KucFaculty of Medicine, Medical University of Bialystok, ul. Kilińskiego 1, 15-089 Bialystok, Poland.

Magdalena SulewskaDepartment of Periodontal and Oral Mucosa Diseases, Medical University of Bialystok, ul. Waszyngtona 13, 15-269 Bialystok, Poland.ORCID 0000-0003-4326-8907

Marzena TylickaDepartment of Medical Biophysics, Medical University of Bialystok, ul. Mickiewicza 2a, 15-089 Bialystok, Poland.ORCID 0000-0002-9594-8173

Michał SarulDepartment of Integrated Dentistry, Wroclaw Medical University, 50-425 Wroclaw, Poland.ORCID 0000-0002-2518-0007

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tooth agenesis is a common developmental anomaly of the human dentition, ranging from hypodontia to oligodontia, yet its marked phenotypic variability remains insufficiently explained. This review synthesizes developmental and molecular evidence on epithelial-mesenchymal interactions during early odontogenesis and proposes a signaling-threshold framework for human tooth agenesis. We focus on the coordinated roles of Wnt/β-catenin, bone morphogenetic protein (BMP), fibroblast growth factor (FGF), and Sonic hedgehog (SHH) pathways and on recurrent disease-associated genes, including

Indexed as

AnodontiaOdontogenesisSignal TransductionAnimalsBone Morphogenetic ProteinsGene Expression Regulation, DevelopmentalHedgehog ProteinsHumansMSX1 Transcription FactorToothWnt ProteinsWnt Signaling PathwayBone Morphogenetic ProteinsHedgehog ProteinsMSX1 Transcription FactorWnt Proteinsbone morphogenetic proteinsgene expression regulationhypodontiaodontogenesisoligodontiaWnt signaling pathway

Identifiers

PMID42196506

DOI10.3390/ijms27104528

PMCPMC13207132

What Socratic holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.