ArticleMolecules (Basel, Switzerland)2026
Triple-Marker Screening of 20 Terpenes Identifies Candidate Modulators of Senescence-Associated Phenotypes in D-Galactose-Treated Endothelial Cells.
Arthur José Pontes Oliveira de Almeida, Larisse Virgolino da Silva Pontes, Javanyr Frederico de Souza Júnior, Evyllen Myllena Cardoso Soares, Adhonias Correia Dos Santos, Tays Amanda Felisberto Gonçalves, Mathania Silva de Almeida Feitosa, Robson Cavalcante Veras, Jose Maria Barbosa Filho, Lisa A Lesniewski and 2 more
Abstract read
In one paragraphArticle in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
12 authors.
Arthur José Pontes Oliveira de AlmeidaPost-Graduate Program in Development and Technological Innovation in Medicines, Health Sciences Center, Federal University of Paraíba, Campus I, João Pessoa 58071-970, PB, Brazil.ORCID 0000-0003-2501-3249 Larisse Virgolino da Silva PontesDepartment of Pharmaceutical Sciences, Health Sciences Center, Federal University of Paraíba, Cidade Universitária-Campus I, João Pessoa 58051-970, PB, Brazil.ORCID 0000-0002-9405-2738 Javanyr Frederico de Souza JúniorPost-Graduate Program in Bioactive Natural and Synthetic Products, Health Sciences Center, Federal University of Paraíba, Campus I, João Pessoa, 58051-900, PB, Brazil.ORCID 0000-0003-0029-3352 Evyllen Myllena Cardoso SoaresDepartment of Pharmaceutical Sciences, Health Sciences Center, Federal University of Paraíba, Cidade Universitária-Campus I, João Pessoa 58051-970, PB, Brazil.
Adhonias Correia Dos SantosPost-Graduate Program in Bioactive Natural and Synthetic Products, Health Sciences Center, Federal University of Paraíba, Campus I, João Pessoa, 58051-900, PB, Brazil.
Tays Amanda Felisberto GonçalvesDepartment of Pharmaceutical Sciences, Health Sciences Center, Federal University of Paraíba, Cidade Universitária-Campus I, João Pessoa 58051-970, PB, Brazil.ORCID 0000-0002-7107-132X Mathania Silva de Almeida FeitosaDepartment of Pharmaceutical Sciences, Health Sciences Center, Federal University of Paraíba, Cidade Universitária-Campus I, João Pessoa 58051-970, PB, Brazil.
Robson Cavalcante VerasDepartment of Pharmaceutical Sciences, Health Sciences Center, Federal University of Paraíba, Cidade Universitária-Campus I, João Pessoa 58051-970, PB, Brazil.ORCID 0000-0002-2083-6898 Jose Maria Barbosa FilhoDepartment of Pharmaceutical Sciences, Health Sciences Center, Federal University of Paraíba, Cidade Universitária-Campus I, João Pessoa 58051-970, PB, Brazil.ORCID 0000-0002-9567-4096 Lisa A LesniewskiNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT 84112, USA.
Anthony J DonatoNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT 84112, USA.
Isac Almeida de MedeirosPost-Graduate Program in Development and Technological Innovation in Medicines, Health Sciences Center, Federal University of Paraíba, Campus I, João Pessoa 58071-970, PB, Brazil.ORCID 0000-0001-8783-4806 Funding
Integrative Mechanisms of Vascular AgingR01AG077751 · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2025 to 2025
$450kTissue senescence and age-associated metabolic dysfunction: the role of immune cell mediated inflammationR01AG076748 · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2025 to 2025
$437kConselho Nacional de Desenvolvimento Científico e Tecnológico 311711/2018-9he Fundação de Apoio à Pesquisa do Estado da Paraiba-Fapesq 47759.673.28850.11082021NIH HHS R01 AG076748NIH HHS R01 AG077751Nora Eccles Treadwell Foundation NETFthe Instituto UFPB de Desenvolvimento da Paraíba IDEPUniversidade Federal da Paraíba-Chamada de Produtividade em Pesquisa PROPESQ/PRPG/UFPB 04/2021-PQ-1 PVG14861-2021
6 · The paper itselfAbstract
Aging is a major risk factor for chronic diseases, including cardiovascular diseases. Endothelial cells (ECs) are particularly vulnerable to age-related stress, and endothelial senescence contributes to vascular aging. In the present study, we applied a triple-screening strategy to identify terpenes that modulate senescence-associated phenotypes in endothelial cells. Rat aortic endothelial cells (RAECs) were exposed to D-galactose to induce a senescence-associated phenotype, and 20 g/L was selected for subsequent experiments. Subsequently, twenty terpenes were tested at four concentrations (10
Indexed as
Cellular SenescenceEndothelial CellsGalactoseTerpenesAnimalsbeta-GalactosidaseBiomarkersCell SurvivalOxidative StressPhenotypeRatsbeta-GalactosidaseBiomarkersGalactoseTerpenesagingantioxidantsendothelial cellsessential oilssenescenceterpenes
Identifiers
PMID42197166
PMCPMC13209231
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390