Evidence map›Paper›PMID 42197515›Full record

ReviewMicroorganisms2026

Structural Advances in Respiratory Syncytial Virus: Implications for Vaccine and Antiviral Development.

Xuanwei Huang, Caner Akıl, Peijun Zhang

Abstract readReview
In one paragraph

Review in Microorganisms, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Xuanwei HuangChinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford OX3 7BN, UK.
Caner AkılChinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford OX3 7BN, UK.ORCID 0000-0002-9464-1903
Peijun ZhangChinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford OX3 7BN, UK.ORCID 0000-0003-1803-691X

Funding

Chinese Academy of Medical Sciences & Peking Union Medical College 2024-I2M-2-001-1European Remanufacturing Council 101021133National Institute of Allergy and Infectious Diseases AI170791National Institute of Allergy and Infectious Diseases AI184080Wellcome Trust 311427/Z/24/Z
6 · The paper itself

Abstract

Respiratory syncytial virus (RSV) remains a leading cause of severe lower respiratory tract disease in infants, older adults, and immunocompromised individuals. Over the past decade, advances in structural biology, particularly cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET), have transformed our understanding of RSV architecture, dynamics, and the mechanisms of entry and replication. High-resolution structures of the prefusion F glycoprotein (pre-F) and its complexes with neutralizing antibodies established the rationale for structure-guided antigen stabilization and directly enabled the development of the first licensed RSV vaccines. Complementary structures of the ribonucleoprotein, polymerase complex, and matrix lattice have broadened therapeutic targets beyond F. Here, we summarize these structural advances; review current structure-guided vaccine, antibody, and antiviral development efforts; and highlight priorities for next-generation vaccines and therapeutics.

Indexed as

antibodiesantiviral strategiescryo-EMcryo-ETmembrane fusionrespiratory syncytial virusstructure-based vaccine design

Identifiers

PMID42197515
PMCPMC13209365

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.