Protective Role of Alpha-Lipoic Acid Against Methotrexate-Induced Osteotoxicity: Mechanisms of Oxidative Stress Regulation and MAPK Pathway Inhibition.

Ahmet Can Haskan, Muhammed Said Altun, Osman Fatih Arpağ, Fariz Selimli, Soner Mete, Percin Pazarci, Halil Mahir Kaplan

Abstract read

In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ahmet Can HaskanDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Hatay Mustafa Kemal University, 31001 Hatay, Turkey.

Muhammed Said AltunDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Hatay Mustafa Kemal University, 31001 Hatay, Turkey.

Osman Fatih ArpağDepartment of Periodontology, Faculty of Dentistry, Hatay Mustafa Kemal University, 31001 Hatay, Turkey.

Fariz SelimliDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Hatay Mustafa Kemal University, 31001 Hatay, Turkey.

Soner MeteMedical Promotion and Marketing Program, Department of Medical Services and Techniques, Medical Vocational Higher Services School, Nevsehir Hacibektas University, 50300 Nevşehir, Turkey.ORCID 0000-0002-8238-8744

Percin PazarciDepartment of Medical Biology, Faculty of Medicine, Cukurova University, 01330 Adana, Turkey.ORCID 0000-0002-3708-0054

Halil Mahir KaplanDepartment of Pharmacology, Faculty of Medicine, Cukurova University, 01330 Adana, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

alpha-lipoic acidMAPKmethotrexateosteotoxicityoxidative stress

Identifiers

PMID42198403

DOI10.3390/ph19050729

PMCPMC13209593

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.