Evidence mapPaperPMID 42198501Full record

ReviewToxics2026

Genetic Polymorphisms as Modifiers of Health Risks from Exposure to Toxic Elements: A Traditional Literature Review.

Mariangela Palazzo, Andrea Borghini, Elisa Bustaffa, Silvia Baldacci, Francesca Gorini, Fabrizio Minichilli

Abstract readReview
In one paragraph

Review in Toxics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mariangela PalazzoInstitute of Clinical Physiology, National Research Council, 56124 Pisa, Italy.
Andrea BorghiniInstitute of Clinical Physiology, National Research Council, 56124 Pisa, Italy.ORCID 0000-0003-1061-8309
Elisa BustaffaInstitute of Clinical Physiology, National Research Council, 56124 Pisa, Italy.
Silvia BaldacciInstitute of Clinical Physiology, National Research Council, 56124 Pisa, Italy.
Francesca GoriniInstitute of Clinical Physiology, National Research Council, 56124 Pisa, Italy.ORCID 0000-0002-4619-6227
Fabrizio MinichilliInstitute of Clinical Physiology, National Research Council, 56124 Pisa, Italy.

Funding

Ministry of Health PRR.AP015.165
6 · The paper itself

Abstract

A growing body of epidemiological and toxicological evidence indicates that exposure to toxic elements (TEs), including As, Cd, Cr(VI), Pb, and Hg, is associated with a wide range of adverse health outcomes, including cancer, neurological and cardiovascular diseases. Given their widespread presence and toxicity, understanding the factors underlying inter-individual differences in susceptibility is essential, as not all exposed individuals develop the same health effects. Genetic variability, particularly single-nucleotide polymorphisms (SNPs), is increasingly recognized as a key determinant of individual responses to TE exposure. Variants in genes involved in metal transport, detoxification, and DNA repair, including

Indexed as

cancer riskcardiovascular diseasegene–environment interactionheavy metalsneurological disorderssingle-nucleotide polymorphismstoxic elements

Identifiers

PMID42198501
PMCPMC13211252

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.