Evidence map›Paper›PMID 42198564›Full record

ArticleToxics2026

Cobinamide, a Vitamin B

Anirudh Kalyanaraman, Connor B Stauffer, Weirui Gao, Tong Zhong, Alexandra Nguyen, Darren E Casteel, Renate B Pilz, Gerry R Boss, Hema Kalyanaraman, John Tat

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anirudh KalyanaramanDepartment of Medicine, University of California, La Jolla, San Diego, CA 92093, USA.
Connor B StaufferDepartment of Medicine, University of California, La Jolla, San Diego, CA 92093, USA.
Weirui GaoDepartment of Medicine, University of California, La Jolla, San Diego, CA 92093, USA.
Tong ZhongDepartment of Medicine, University of California, La Jolla, San Diego, CA 92093, USA.
Alexandra NguyenDepartment of Medicine, University of California, La Jolla, San Diego, CA 92093, USA.ORCID 0009-0006-7541-420X
Darren E CasteelDepartment of Medicine, University of California, La Jolla, San Diego, CA 92093, USA.ORCID 0000-0002-7673-6597
Renate B PilzDepartment of Medicine, University of California, La Jolla, San Diego, CA 92093, USA.
Gerry R BossDepartment of Medicine, University of California, La Jolla, San Diego, CA 92093, USA.
Hema KalyanaramanDepartment of Medicine, University of California, La Jolla, San Diego, CA 92093, USA.ORCID 0000-0003-4870-937X
John TatDepartment of Medicine, University of California, La Jolla, San Diego, CA 92093, USA.ORCID 0009-0006-7578-8738

Funding

Mechanisms of vascular pathology from abnormal protein kinase G signalingR01HL132141 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PILZ, RENATE B · 2016 to 2025
$4.5M
Development of the Vitamin B12 Analog cobinamide as a Hydrogen Sulfide AntidoteU01NS087964 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BOSS, GERRY R · 2015 to 2019
$4.3M
NHLBI NIH HHS R01 HL132141NINDS NIH HHS U01 NS087964
6 · The paper itself

Abstract

Polycyclic aromatic hydrocarbons (PAHs) are common environmental contaminants formed during the incomplete combustion of organic material. Their persistence, bioaccumulation, and metabolic activation contribute to mutagenic and cytotoxic outcomes. Among these are benzo[a]pyrene (B[a]P), the most studied PAH and a benchmark compound for PAH carcinogenicity, and pyrene, a PAH whose urinary metabolite 1-hydroxypyrene is widely used as a biomarker of PAH exposure. B[a]P undergoes CYP1A1-mediated oxidation to generate reactive oxygen species (ROS) via epoxide and quinone redox cycling, whereas pyrene produces ROS primarily through pyrene-quinone redox cycling. We investigated cobinamide, a vitamin B

Indexed as

antioxidant therapybenzo[a]pyrenecobinamideoxidative stresspyrenereactive oxygen species (ROS)toxicity mitigation

Identifiers

PMID42198564
PMCPMC13211721

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.