Discovery of Synthetic Imine-Chalcones Targeting Mayaro Virus Replication.

Leonardo Dos Santos Corrêa-Amorim, Natasha Cristina da Rocha, Geicy Kelly P Barboza, Mariana F L P Carlos, Aurea Echevarria, Vitor Won-Held Rabelo, Izabel Christina Nunes de Palmer Paixão

Abstract read

PubMed Full text at PMC Publisher

In one paragraph

Article in Pathogens (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Leonardo Dos Santos Corrêa-AmorimLaboratório de Virologia Molecular e Biotecnologia Marinha, Programa de Pós-Graduação em Ciências e Biotecnologia, Departamento de Biologia Celular e Molecular, Instituto de Biologia, Universidade Federal Fluminense, Niterói 24210-201, RJ, Brazil.ORCID 0000-0001-8413-0862

Natasha Cristina da RochaLaboratório de Virologia Molecular e Biotecnologia Marinha, Programa de Pós-Graduação em Ciências e Biotecnologia, Departamento de Biologia Celular e Molecular, Instituto de Biologia, Universidade Federal Fluminense, Niterói 24210-201, RJ, Brazil.

Geicy Kelly P BarbozaInstituto de Química, Departamento de Química Orgânica, Universidade Federal Rural do Rio de Janeiro, Seropédica 23897-000, RJ, Brazil.ORCID 0000-0002-9886-643X

Mariana F L P CarlosInstituto de Química, Departamento de Química Orgânica, Universidade Federal Rural do Rio de Janeiro, Seropédica 23897-000, RJ, Brazil.ORCID 0000-0002-0342-1738

Aurea EchevarriaInstituto de Química, Departamento de Química Orgânica, Universidade Federal Rural do Rio de Janeiro, Seropédica 23897-000, RJ, Brazil.ORCID 0000-0002-7330-676X

Vitor Won-Held RabeloDepartamento de Virologia, Instituto de Microbiologia Paulo de Góes, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil.ORCID 0000-0001-5303-6814

Izabel Christina Nunes de Palmer PaixãoLaboratório de Virologia Molecular e Biotecnologia Marinha, Programa de Pós-Graduação em Ciências e Biotecnologia, Departamento de Biologia Celular e Molecular, Instituto de Biologia, Universidade Federal Fluminense, Niterói 24210-201, RJ, Brazil.ORCID 0000-0001-7513-2567

Funding

Conselho Nacional de Desenvolvimento Científico e TecnológicoCoordenação de Aperfeicoamento de Pessoal de Nível Superior 001Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro

6 · The paper itself

Abstract

Mayaro virus (MAYV) is an arthritogenic alphavirus transmitted by mosquitoes and is the causative agent of Mayaro fever. This disease is associated with symptoms such as arthralgia and myalgia, which may persist for months or even years. Currently, no vaccine or specific antiviral therapy is available. This study aimed to assess the antiviral activity of synthetic imine-chalcone derivatives (

Indexed as

AlphavirusAntiviral AgentsChalconesIminesVirus ReplicationAnimalsChlorocebus aethiopsVero CellsAntiviral AgentsChalconesIminesantiviralarboviruseschalconeflavonoidMayaro virus

Identifiers

PMID42198655

DOI10.3390/pathogens15050529

PMCPMC13209878

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.