Evidence map›Paper›PMID 42198780›Full record

ArticleViruses2026

Aerosol Inhalation of a Recombinant H7N9 Hemagglutinin Antigen Elicits Systemic and Mucosal Immune Responses in Mice.

Zhuoran Hou, Han Wang, Bin Zhang, Ruixi Liu, Yuli Zhang, Ye Yang, Jianxin Wu, Xuchen Hou, Xiuguo Ge, Jun Wu and 1 more

Abstract read
In one paragraph

Article in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhuoran HouTianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin 300392, China.
Han WangNational Key Laboratory of Advanced Biotechnology, Academy of Military Medical Sciences, Beijing 100071, China.
Bin ZhangNational Key Laboratory of Advanced Biotechnology, Academy of Military Medical Sciences, Beijing 100071, China.
Ruixi LiuNational Key Laboratory of Advanced Biotechnology, Academy of Military Medical Sciences, Beijing 100071, China.
Yuli ZhangNational Key Laboratory of Advanced Biotechnology, Academy of Military Medical Sciences, Beijing 100071, China.
Ye YangNational Key Laboratory of Advanced Biotechnology, Academy of Military Medical Sciences, Beijing 100071, China.
Jianxin WuNational Key Laboratory of Advanced Biotechnology, Academy of Military Medical Sciences, Beijing 100071, China.
Xuchen HouNational Key Laboratory of Advanced Biotechnology, Academy of Military Medical Sciences, Beijing 100071, China.
Xiuguo GeTianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin 300392, China.
Jun WuNational Key Laboratory of Advanced Biotechnology, Academy of Military Medical Sciences, Beijing 100071, China.
Bo LiuNational Key Laboratory of Advanced Biotechnology, Academy of Military Medical Sciences, Beijing 100071, China.ORCID 0000-0001-6655-1866

Funding

Beijing Institute of Biotechnology 2022YFC2104801
6 · The paper itself

Abstract

Highly pathogenic avian influenza A (H7N9) remains a threat to poultry health and poses a zoonotic risk, highlighting the need for vaccine antigens capable of inducing both systemic and mucosal immunity. In this study, we evaluated X33CLS-H7, a clarified cell-lysate supernatant derived from glycoengineered

Indexed as

Hemagglutinin Glycoproteins, Influenza VirusImmunity, MucosalInfluenza A Virus, H7N9 SubtypeInfluenza VaccinesOrthomyxoviridae InfectionsAdministration, InhalationAerosolsAnimalsAntibodies, ViralBronchoalveolar Lavage FluidFemaleHemagglutination Inhibition TestsImmunoglobulin AImmunoglobulin GMiceMice, Inbred BALB CAerosolsAntibodies, ViralHemagglutinin Glycoproteins, Influenza VirusImmunoglobulin AImmunoglobulin GInfluenza VaccinesRecombinant ProteinsA(H7N9) influenzahemagglutininimmunogenicitymucosal vaccinationyeast expression

Identifiers

PMID42198780
PMCPMC13211749

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.