ArticlePain research & management2026
Chronic Overlapping Pain and Central Sensitization in Chronic Pelvic Pain: Do Positive and Negative Affect Play a Role?
Article in Pain research & management, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Integrating the Central Sensitization Inventory (CSI) into Neuropelveological Practice: A Systematic Review of Endometriosis and Overlapping Pelvic Pain Syndromes.Journal of clinical medicine · 2026Review
- Chronic Overlapping Pain and Central Sensitization in Chronic Pelvic Pain: Do Positive and Negative Affect Play a Role?Pain research & management · 2026Article
- Understanding risk and protective factors for pain and healthy aging: an intersectional and resilience-based perspective.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Chronic pelvic pain (CPP) has a complex etiology and a high degree of coprevalence with other chronic overlapping pain conditions (COPCs). Evidence suggests that central sensitization contributes to these conditions; however, the psychological risk and resilience factors influencing the relationship between COPCs and central sensitization have received limited attention. Therefore, the aim of this study was to examine whether positive and negative affect moderate the relationship between COPCs and central sensitization in individuals with CPP. Participants (N = 197) completed the Central Sensitization Inventory and Positive and Negative Affect Schedule and self-reported the presence of diagnosed COPCs. Results indicated that greater symptoms of central sensitization were associated with a greater number of COPCs (p < 0.01). Higher levels of positive affect were related to lower central sensitization (p < 0.01) and fewer COPCs (p < 0.05), while higher negative affect was associated with greater central sensitization (p < 0.01). After controlling for pelvic pain duration, a greater number of COPCs were associated with greater central sensitization, but only among individuals with lower positive affect (p = 0.01). No significant moderation effects were observed for negative affect (p = 0.13). The findings from this cross-sectional study suggest that lower positive affect may have an adverse effect on central sensitization in those with a greater number of COPCs. Individuals with CPP, especially those experiencing multiple chronic pain conditions, may benefit from interventions aimed at increasing positive affect.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.