Evidence map›Paper›PMID 42199209›Full record

ArticleFrontiers in cardiovascular medicine2026

High-fat diet-induced obesity impairs endothelium-dependent relaxation in rabbits: association with MLCK upregulation and partial

Jiao Li, Jiantao Zhou, Qingxu Ha, Junwei Gu, Hui Yuan, Juan Cheng, Xiaojun Zha, Jingjing Teng, Liang Li, Junli Ding

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In one paragraph

Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Jiao Li *Department of Pediatrics, First Affiliated Hospital of Anhui Medical University, Hefei, China.
Jiantao Zhou *Department of Pediatrics, First Affiliated Hospital of Anhui Medical University, Hefei, China.
Qingxu Ha *Department of Pediatrics, First Affiliated Hospital of Anhui Medical University, Hefei, China.
Junwei GuDepartment of Pediatrics, First Affiliated Hospital of Anhui Medical University, Hefei, China.
Hui YuanAnhui Center for Disease Control and Prevention, Public Health Research Institute of Anhui Province, Hefei, China.
Juan ChengDepartment of Physiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Xiaojun ZhaDepartment of Biochemistry & Molecular Biology, School of Basic Medicine, Anhui Medical University, Hefei, China.
Jingjing TengAnhui Center for Disease Control and Prevention, Public Health Research Institute of Anhui Province, Hefei, China.
Liang LiDepartment of Ultrasound, First Affiliated Hospital of Anhui Medical University, Hefei, China.
Junli DingDepartment of Pediatrics, First Affiliated Hospital of Anhui Medical University, Hefei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Obesity is an independent risk factor for cardiovascular diseases and elevated mortality, yet the underlying mechanisms remain incompletely understood. Impaired endothelium-dependent relaxation is an early manifestation of vascular injury. This study investigated the impact of high-fat diet (HFD)-induced obesity on endothelium-dependent relaxation function and explored the potential role of myosin light chain kinase (MLCK) signaling in a rabbit model. Methods: Forty-five male New Zealand White rabbits were randomized into control (normal diet), HFD, and ML-7 (HFD plus the MLCK inhibitor ML-7, 1 mg/kg/day) groups ( Results: HFD-fed rabbits developed obesity (body weight +27.85% vs. control), dyslipidemia (elevated TC, LDL-C, and ox-LDL; all Conclusions: Obesity-induced endothelial dysfunction is associated with visceral fat accumulation, dyslipidemia, and MLCK upregulation. MLCK inhibition with ML-7 partially restored endothelium-dependent relaxation

Indexed as

dyslipidemiaendothelial dysfunctionML-7MLCKobesityPRAT

Identifiers

PMID42199209
PMCPMC13199124

What Socratic holds

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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.