Evidence map›Paper›PMID 42199503›Full record

ArticleInternational journal of vascular medicine2026

Serum Activin A Level and 1-Year Mortality in Atrial Septal Defect-Associated Pulmonary Artery Hypertension: A Case-Control Study From the COHARD-PH Registry.

Pranindya Rinastiti, Anggoro Budi Hartopo, Cindy Elica Cipta, Syallom Gita Maharani, Dyah Wulan Anggrahini, Noriaki Emoto, Lucia Kris Dinarti

Abstract read
In one paragraph

Article in International journal of vascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pranindya RinastitiDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada-Dr. Sardjito Hospital, Yogyakarta, Indonesia, ugm.ac.id.ORCID https://orcid.org/0009-0009-9316-4234
Anggoro Budi HartopoDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada-Dr. Sardjito Hospital, Yogyakarta, Indonesia, ugm.ac.id.ORCID https://orcid.org/0000-0002-6373-1033
Cindy Elica CiptaDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada-Dr. Sardjito Hospital, Yogyakarta, Indonesia, ugm.ac.id.ORCID https://orcid.org/0009-0008-6338-1943
Syallom Gita MaharaniDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada-Dr. Sardjito Hospital, Yogyakarta, Indonesia, ugm.ac.id.
Dyah Wulan AnggrahiniDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada-Dr. Sardjito Hospital, Yogyakarta, Indonesia, ugm.ac.id.ORCID https://orcid.org/0000-0001-6454-518X
Noriaki EmotoLaboratory of Clinical Pharmaceutical Science, Kobe Pharmaceutical University, Kobe, Japan, kobepharma-u.ac.jp.ORCID https://orcid.org/0000-0001-6673-2616
Lucia Kris DinartiDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada-Dr. Sardjito Hospital, Yogyakarta, Indonesia, ugm.ac.id.ORCID https://orcid.org/0000-0002-4011-2184

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Serum activin A level is a promising prognostic biomarker for pulmonary artery hypertension (PAH). In this study, we aim to investigate serum activin A levels and their associations with 1-year mortality in atrial septal defect (ASD)-associated PAH patients. Methods: This was a case-control study of adult Indonesian patients diagnosed with ASD-PAH from the COHARD-PH registry. Cases were subjects deceased in a 1-year follow-up, whereas controls were those survived. Serum activin A was measured at the index of diagnosis. The demographics, clinical parameters, hemodynamic, and mortality data were retrieved from the registry database up to a 1-year follow-up period. These data were compared and analyzed between the case and control groups. Results: From the 1-year follow-up data, 44 cases (deceased group) and 102 controls (survived group) were identified. The deceased group had significant lower bodyweight ( Conclusion: Serum activin A level did not associate with 1-year mortality in adult patients with ASD-associated PAH.

Identifiers

PMID42199503
PMCPMC13200696

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.