ArticleOphthalmology science2026
Triglyceride-Glucose Indexes Are Predictive of Early and Severe Diabetic Retinal Microvascular Abnormalities: A Prospective Cohort Study.
Article in Ophthalmology science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Association Between Cardiometabolic Index and Diabetic Retinopathy in Patients with Type 2 Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To evaluate the associations of the triglyceride-glucose (TyG) index and TyG-derived metrics with diabetic retinopathy (DR) subtypes, retinal lesions, and retinal vascular metrics in adults with type 2 diabetes (T2D). Design: A population-based, prospective cohort study. Participants: One thousand nine hundred sixty adults with T2D, followed for a mean of 21.2 months. Methods: Outcomes included ETDRS-graded DR subtypes (advanced DR, vision-threatening DR [VTDR], diabetic macular edema [DME]); retinal lesions (hemorrhages/microaneurysms, hard exudates, soft exudates [SE]); and retinal vascular metrics (central retinal artery equivalent, central retinal vein equivalent, arteriole-to-venule ratio). Associations of TyG and TyG-derived indices with these outcomes were assessed using regression models with multivariable adjustments. Restricted cubic spline regression was applied to test for nonlinear associations. Mediation analyses by hemoglobin A1c (HbA1c) were conducted with bootstrap replications. Bonferroni correction was applied to control for type I error. Main Outcome Measures: Associations of TyG and TyG-derived indices with prevalent and incident DR subtypes, retinal lesions, and retinal vascular metrics. Results: At baseline, TyG and TyG-WHR (TyG × waist-to-hip ratio) were significantly associated ( Conclusions: The TyG and its derived indices (TyG-WHR, TyG-WHtR) are associated with the presence and progression of early and severe retinal vascular abnormalities in T2D. These markers may aid in identifying patients at high risk for VTDR. Financial Disclosures: The authors have no proprietary or commercial interest in any materials discussed in this article.
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Registered trials
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