ArticleFrontiers in nutrition2026
Association of cholesterol, high-density lipoprotein, and glucose (CHG) index with chronic kidney disease in Chinese community adults: findings from the REACTION study.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: While a limited-scale study in Turkey identified an association between the cholesterol, high-density lipoprotein, and glucose (CHG) index and diabetic nephropathy, evidence on the relationship between the CHG index and chronic kidney disease (CKD) is lacking in Chinese general population. This study aimed to investigate the association of CHG index with CKD in this specific demographic. Methods: A total of 9,095 Chinese participants aged ≥40 years were recruited from five regional communities of Luzhou city between May 2011 and December 2011. CHG index was calculated, and its possible relationships with CKD were evaluated by multivariate logistic regression analyses. Receiver operating characteristic (ROC) analysis was conducted to identify the predictive performance, and subgroup analysis evaluated its applicability in different populations. Results: The subjects with higher CHG index quartiles had significantly higher prevalence of CKD compared to those with lower quartiles ( Conclusion: The CHG index was closely associated with CKD, and might be a potential biomarker for CKD in Chinese community adults.
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