ArticleFrontiers in nutrition2026
Associations of the triglyceride-glucose index and its composite indices with mortality in adults with T2DM.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The triglyceride-glucose (TyG) index and its composite indices have emerged as potential markers for metabolic risk, but their prognostic value for mortality in middle-aged and older adults with T2DM remains incompletely defined. Methods: We analyzed data from 1,940 adults with T2DM (aged ≥45 years) who underwent routine health examinations. Baseline characteristics were described using mean (SD), median (IQR), and count (%). Cox proportional hazards regression models were constructed to evaluate associations of TyG-related indices (TyG-WC, TyG-WHR, TyG-WHtR, TyG-ABSI, TyG-WWI) with all-cause mortality, with adjustment for confounders. Restricted cubic splines (RCS) were used to explore nonlinear relationships, and time-dependent ROC curves assessed predictive performance. Subgroup analyses were stratified by age, sex, smoking, drinking, and hypertension status. Results: During follow-up, 312 (16.1%) participants died. In fully adjusted models, TyG-WC, TyG-WHtR, TyG-ABSI, and TyG-WWI were independently associated with increased mortality (HR range: 1.21-1.44, all Conclusion: TyG composite indices, particularly TyG-WHtR, TyG-ABSI, and TyG-WWI, are independent predictors of all-cause mortality in middle-aged and older adults with T2DM, offering potential utility for long-term mortality risk stratification.
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