ArticleWorld journal of emergency medicine2026
Protective role of local hypothermia in taurocholate-induced acute pancreatitis: an
Article in World journal of emergency medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
backgroundAcute pancreatitis (AP) is an inflammatory disease characterized by pancreatic autodigestion and systemic inflammatory responses, which can lead to severe complications and high mortality. Hypothermia has shown potential protective effects against AP-related injury; however, the metabolic mechanisms underlying hypothermia-mediated protection against AP remain unclear. In this study, we aimed to investigate serum metabolic changes in a rat model of AP treated with hypothermia with intragastric cooling and to identify potential protective metabolites and explore their biological roles.
methodsThe entire study included both
results
conclusionIn this study, local hypothermia attenuated inflammatory cytokine release, serum amylase elevation, and pancreatic injury in a rat model of AP. These protective effects may be associated with the upregulation of serum pinitol and tocopherol levels. These metabolites may exert potential protective effects through pathways related to inflammation and oxidative stress.
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