Article in Medical sciences (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
19 authors.
André Nogueira Cardeal Dos SantosExperimental Physiology Laboratory, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza 60714-903, CE, Brazil.ORCID 0009-0002-7008-8901
José Ednésio da Cruz FreireBiochemistry and Gene Expression Laboratory, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza 60714-903, CE, Brazil.ORCID 0000-0002-0660-0459
Francisco Sydney Henrique FélixExperimental Physiology Laboratory, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza 60714-903, CE, Brazil.
Marília Cavalcante AraújoExperimental Physiology Laboratory, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza 60714-903, CE, Brazil.
Savyo Mikael Lacerda GomesExperimental Physiology Laboratory, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza 60714-903, CE, Brazil.ORCID 0009-0000-3698-8522
Alexandre Lucas Lima França CabralExperimental Physiology Laboratory, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza 60714-903, CE, Brazil.ORCID 0009-0007-6423-7524
Amanda Batista NascimentoExperimental Physiology Laboratory, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza 60714-903, CE, Brazil.ORCID 0000-0002-2332-154X
Cleisla Costa BarbosaExperimental Physiology Laboratory, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza 60714-903, CE, Brazil.ORCID 0009-0001-9720-9251
Marcus Vinícius Vieira TorquatoExperimental Physiology Laboratory, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza 60714-903, CE, Brazil.ORCID 0009-0003-8329-1121
Lívia de Souza OliveiraExperimental Physiology Laboratory, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza 60714-903, CE, Brazil.ORCID 0009-0006-3860-4100
Luiz Henrique Batista AssunçãoExperimental Physiology Laboratory, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza 60714-903, CE, Brazil.ORCID 0009-0009-1290-1707
Sofia Moura de Sousa BrasilExperimental Physiology Laboratory, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza 60714-903, CE, Brazil.
Cecília Bessa FreitasExperimental Physiology Laboratory, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza 60714-903, CE, Brazil.ORCID 0009-0000-8659-1945
Julianne Ferreira da SilvaExperimental Physiology Laboratory, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza 60714-903, CE, Brazil.
João Henrique Andrade de MenezesExperimental Physiology Laboratory, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza 60714-903, CE, Brazil.ORCID 0009-0007-9537-1179
Átila Pereira-GonçalvesExperimental Physiology Laboratory, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza 60714-903, CE, Brazil.ORCID 0000-0002-4729-3168
José Henrique Leal-CardosoElectrophysiology Laboratory, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza 60714-903, CE, Brazil.ORCID 0000-0002-3972-1361
Adélia Justina Aguiar AquinoDepartment of Mechanical Engineering and Aerospace, Texas Tech University, Lubbock, TX 79409, USA.
Andrelina Noronha Coelho de SousaExperimental Physiology Laboratory, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza 60714-903, CE, Brazil.ORCID 0000-0002-7357-0958
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
backgroundElectromechanical coupling is a fundamental process in the regulation of vascular smooth muscle contraction. It is characterized by changes in electrical potential membrane (depolarization). Voltage-gated calcium channels (VGCCs) play a central role in this process by mediating calcium influx necessary for vascular contraction. As highly conserved macromolecules in mammals, VGCCs represent translationally relevant targets for the development of vasorelaxant agents. Inhibition of these channels reduces calcium influx and attenuates the tonic smooth muscle contraction, making them strategic targets for novel therapeutic approaches. This is particularly important given the high prevalence of cardiovascular diseases, which remain the leading cause of global mortality.
methodsThe aim of this study is to investigate the mechanism of action of terpenes in VGCCs. Terpenes are phytochemicals that have been widely studied as drug candidates. To this end, the oil from
resultsIn vitro assays on isolated aortic rings, with and without endothelium, demonstrated that these compounds reverse and block KCl (80 mM)-induced contractions in an endothelium-independent manner.
conclusionsAnalyses of the ionic influx of calcium and barium indicated a progressive blockade of contraction, reinforcing the hypothesis of a direct interaction with the macromolecules of the VGCCs. Computational analyses, for the first time, suggest a potential synergistic interaction among terpenes in their binding to these macromolecules.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.