Evidence map›Paper›PMID 42201073›Full record

ArticleJournal of xenobiotics2026

Genotoxic Damage and microRNA Dysregulation in Firefighters: An Integrated Biomonitoring Case Study.

Claudia Cipollone, Riccardo Mastrantonio, Paola Mozzoni, Giada Mastrangeli, Massimo Corradi, Stefano Renzetti, Veronica Saponara, Maria Nicastro, Delia Cavallo, Raffaele Maiello and 11 more

Abstract read
In one paragraph

Article in Journal of xenobiotics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Claudia CipolloneOccupational Medicine Unit, Abruzzo Local Health Authority No. 1, 67100 L'Aquila, Italy.ORCID 0000-0002-0940-2124
Riccardo MastrantonioDepartment of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.ORCID 0000-0002-0465-3784
Paola MozzoniDepartment of Medicine and Surgery, University of Parma, 43126 Parma, Italy.ORCID 0000-0002-6883-8040
Giada MastrangeliDepartment of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.ORCID 0009-0005-5715-2632
Massimo CorradiDepartment of Medicine and Surgery, University of Parma, 43126 Parma, Italy.ORCID 0000-0002-2808-4184
Stefano RenzettiDepartment of Medicine and Surgery, University of Parma, 43126 Parma, Italy.ORCID 0000-0002-4467-765X
Veronica SaponaraDepartment of Medicine and Surgery, University of Parma, 43126 Parma, Italy.ORCID 0009-0009-2324-4773
Maria NicastroDepartment of Medicine and Surgery, University of Parma, 43126 Parma, Italy.
Delia CavalloDepartment of Occupational and Environmental Medicine, Epidemiology and Hygiene, Italian Workers' Compensation Authority-INAIL, Monte Porzio Catone, 00078 Rome, Italy.ORCID 0000-0002-2331-1464
Raffaele MaielloDepartment of Occupational and Environmental Medicine, Epidemiology and Hygiene, Italian Workers' Compensation Authority-INAIL, Monte Porzio Catone, 00078 Rome, Italy.
Marco GentileDepartment of Occupational and Environmental Medicine, Epidemiology and Hygiene, Italian Workers' Compensation Authority-INAIL, Monte Porzio Catone, 00078 Rome, Italy.
Diana PoliDepartment of Occupational and Environmental Medicine, Epidemiology and Hygiene, Italian Workers' Compensation Authority-INAIL, Monte Porzio Catone, 00078 Rome, Italy.ORCID 0000-0001-6885-4473
Mario MuselliDepartment of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
Alessia RomantiniDepartment of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
Giorgia Di GennaroDepartment of Occupational and Environmental Medicine, Epidemiology and Hygiene, Italian Workers' Compensation Authority-INAIL, Monte Porzio Catone, 00078 Rome, Italy.ORCID 0000-0003-2358-5649
Gloria CenciDepartment of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, 43124 Parma, Italy.ORCID 0009-0005-9641-2599
Carmela ProtanoDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-7668-5809
Matteo VitaliDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-1001-6343
Giuseppe De PalmaUnit of Occupational Health and Industrial Hygiene, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0001-9821-3060
Cinzia Lucia UrsiniDepartment of Occupational and Environmental Medicine, Epidemiology and Hygiene, Italian Workers' Compensation Authority-INAIL, Monte Porzio Catone, 00078 Rome, Italy.
Leila FabianiDepartment of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.ORCID 0000-0002-0597-1450

Funding

Istituto Nazionale per l'Assicurazione Contro gli Infortuni sul Lavoro BRiC-2022, project number ID51/2022.
6 · The paper itself

Abstract

Firefighters are potentially exposed to multiple harmful substances, and their activities are classified as carcinogenic to humans. This case study assessed early genotoxic damage (fpg-comet and BMCyt assays) and epigenetic alterations (seven circulating miRNAs) in 35 firefighters compared to 45 non-exposed workers. Occupational exposure to fire smoke was self-reported via questionnaire. Firefighters showed higher median genotoxic DNA damage with respect to the non-exposed group (%DNA tail Buff 19.4 vs. 16.8; %DNA tail Enz 22.2 vs. 19.3; Tail moment 5.5 vs. 4.5; % of apoptotic cells 1.13 vs. 0.97). miRNAs related to air pollution, oxidative stress, tumor suppression, and immune responses, like mir-16, mir-15a, mir-29a, mir-125b, and mir-142, showed significant downregulation (

Indexed as

DNA damageepigenetic effectfirefighterfirefightinghuman biomonitoringmiRNAoccupational exposureoxidative damage

Identifiers

PMID42201073
PMCPMC13214885

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.