Evidence map›Paper›PMID 42201077›Full record

ArticleJournal of xenobiotics2026

Exposure to Endocrine Disruptors and Stress Hormones Across Pregnancy Trimesters: Links with Maternal Telomere Length.

Elena Vakonaki, Eleftheria Hatzidaki, Stella Baliou, Maria Marmara, Athanasios Alegakis, Eleftheria Mylonaki, Zoi Volonaki, Fanourios Makrygiannakis, Aristides Tsatsakis, Manolis N Tzatzarakis

Abstract read
In one paragraph

Article in Journal of xenobiotics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Elena VakonakiLaboratory of Toxicology, School of Medicine, University of Crete, 71003 Heraklion, Greece.
Eleftheria HatzidakiDepartment of Neonatology, Neonatal Intensive Care Unit, University Hospital of Heraklion and School of Medicine, University of Crete, 70013 Heraklion, Greece.ORCID 0000-0001-6256-3309
Stella BaliouLaboratory of Toxicology, School of Medicine, University of Crete, 71003 Heraklion, Greece.
Maria MarmaraLaboratory of Toxicology, School of Medicine, University of Crete, 71003 Heraklion, Greece.ORCID 0009-0003-3453-9696
Athanasios AlegakisLaboratory of Toxicology, School of Medicine, University of Crete, 71003 Heraklion, Greece.ORCID 0000-0001-6507-8691
Eleftheria MylonakiDepartment of Neonatology, Neonatal Intensive Care Unit, University Hospital of Heraklion and School of Medicine, University of Crete, 70013 Heraklion, Greece.
Zoi VolonakiDepartment of Obstetrics and Gynecology, University Hospital of Heraklion, 71500 Heraklion, Greece.
Fanourios MakrygiannakisDepartment of Obstetrics and Gynecology, University Hospital of Heraklion, 71500 Heraklion, Greece.ORCID 0000-0002-2413-9176
Aristides TsatsakisLaboratory of Toxicology, School of Medicine, University of Crete, 71003 Heraklion, Greece.ORCID 0000-0003-3824-2462
Manolis N TzatzarakisLaboratory of Toxicology, School of Medicine, University of Crete, 71003 Heraklion, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExposure of pregnant women to stress and endocrine-disrupting chemicals (EDCs) during pregnancy can have a substantial impact on mother and infant health. We investigated the concentrations of EDCs, such as parabens (PBs) and triclosan (TCS), as well as stress hormones (cortisone and cortisol), across pregnancy trimesters and examined their associations with maternal average telomere length (TL).

methodsHair samples from 49 postpartum women were analyzed using liquid chromatography-mass spectrometry (LC-MS) to quantify EDCs and stress hormone concentrations.

resultsThe mean methyl paraben concentrations in the hair of postpartum women were prevalent across all pregnancy trimesters, while butyl paraben was detected at the lowest levels. The mean concentration of PBs followed the order methyl > propyl > ethyl > benzyl > butyl paraben across pregnancy trimesters. We found that ethyl paraben and triclosan were each positively and significantly associated with cortisol levels in postpartum women's hair. Consistent with this, the mean cortisone concentration gradually increased from the first to the third pregnancy trimester, whereas cortisol reached the highest mean concentration at the second trimester. A significant positive association between cortisol and cortisone levels was observed. Further analyses revealed that mothers' average TL was positively associated with ethylparaben and triclosan levels and inversely associated with benzylparaben levels. Last but not least, we found that cortisol/cortisone levels were positively associated with postpartum women's TL in a statistically significant manner.

conclusionsIn the present study, prenatal exposure to stress hormones and EDCs appears to exert a statistically significant impact on maternal TL dynamics.

Indexed as

biomonitoringcortisolcortisonehairparabenspregnancytelomerestriclosan

Identifiers

PMID42201077
PMCPMC13214751

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.