Evidence map›Paper›PMID 42201086›Full record

ArticleJournal of xenobiotics2026

Real-World Traffic-Polluted Air and Its Impact on a 3D Model of the Human Airway Epithelium.

Michal Sima, Helena Libalova, Zuzana Simova, Kristyna Vrbova, Antonin Ambroz, Jiri Klema, Lubos Dittrich, Michal Vojtisek-Lom, Pavel Rossner

Abstract read
In one paragraph

Article in Journal of xenobiotics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Michal SimaDepartment of Toxicology and Molecular Epidemiology, Institute of Experimental Medicine CAS, Videnska 1083, 142 00 Prague, Czech Republic.ORCID 0000-0001-6927-8615
Helena LibalovaDepartment of Toxicology and Molecular Epidemiology, Institute of Experimental Medicine CAS, Videnska 1083, 142 00 Prague, Czech Republic.
Zuzana SimovaDepartment of Toxicology and Molecular Epidemiology, Institute of Experimental Medicine CAS, Videnska 1083, 142 00 Prague, Czech Republic.ORCID 0009-0002-4993-0607
Kristyna VrbovaDepartment of Toxicology and Molecular Epidemiology, Institute of Experimental Medicine CAS, Videnska 1083, 142 00 Prague, Czech Republic.
Antonin AmbrozDepartment of Toxicology and Molecular Epidemiology, Institute of Experimental Medicine CAS, Videnska 1083, 142 00 Prague, Czech Republic.
Jiri KlemaDepartment of Computer Science, Czech Technical University in Prague, Karlovo Namesti 13, 121 35 Prague, Czech Republic.ORCID 0000-0003-1753-9435
Lubos DittrichFaculty of Mechatronics, Informatics and Interdisciplinary Studies, Technical University of Liberec, Studentska 1402/2, 461 17 Liberec, Czech Republic.
Michal Vojtisek-LomFaculty of Mechatronics, Informatics and Interdisciplinary Studies, Technical University of Liberec, Studentska 1402/2, 461 17 Liberec, Czech Republic.ORCID 0000-0002-8807-0921
Pavel RossnerDepartment of Toxicology and Molecular Epidemiology, Institute of Experimental Medicine CAS, Videnska 1083, 142 00 Prague, Czech Republic.ORCID 0000-0001-6921-5446

Funding

Czech Science Foundation 22-10279SMinistry of Education Youth and Sports 90253
6 · The paper itself

Abstract

Exposure to air pollution is linked to adverse health outcomes. To better reflect real-world conditions, we employed a mobile exposure system enabling direct field exposure of the human airway epithelial model MucilAir™ to ambient air in a traffic-burdened locality. This study represents a follow-up to our previous work, in which a 5-day exposure period under extreme traffic-related pollution conditions resulted in premature cell loss. Under different meteorological conditions characterized by increased precipitation and lower particle number concentrations, MucilAir™ cultures were exposed to traffic-polluted air for 2 days. The exposure resulted in a mild but significant increase in cytotoxicity markers, including lactate dehydrogenase release and elevated levels of 15-F

Indexed as

air pollutioncytotoxicitylung tissue modelreal-world exposuretraffictranscriptomics

Identifiers

PMID42201086
PMCPMC13214726

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.