Evidence map›Paper›PMID 42201342›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2026

Neuroprotective effects of luteolin against aluminum-induced brain injury via chelation and antioxidant pathways.

Şeyma Aydın, Elif Dalkılınç, Selçuk Özdemir, Sefa Küçükler, Selim Çomaklı, Ahmet Adıgüzel

Abstract read
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Şeyma AydınDepartment of Molecular Biology and Genetics, Faculty of Science, Atatürk University, Erzurum, Türkiye.ORCID http://orcid.org/0009-0009-5640-3363
Elif DalkılınçDepartment of Biochemistry, Faculty of Veterinary Medicine, Atatürk University, Erzurum, Türkiye.ORCID http://orcid.org/0009-0005-1008-111X
Selçuk ÖzdemirDepartment of Genetics, Faculty of Veterinary Medicine, Atatürk University, Erzurum, Türkiye. selcuk.ozdemir@atauni.edu.tr.ORCID http://orcid.org/0000-0001-7539-0523
Sefa KüçüklerDepartment of Biochemistry, Faculty of Veterinary Medicine, Atatürk University, Erzurum, Türkiye.ORCID http://orcid.org/0000-0002-8222-5515
Selim ÇomaklıDepartment of Pathology, Faculty of Veterinary Medicine, Atatürk University, Erzurum, Türkiye.ORCID http://orcid.org/0000-0002-8744-7686
Ahmet AdıgüzelDepartment of Molecular Biology and Genetics, Faculty of Science, Atatürk University, Erzurum, Türkiye. adiguzel@atauni.edu.tr.ORCID http://orcid.org/0000-0001-8848-6647

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aluminum (Al) is a widespread environmental neurotoxin linked to several neurodegenerative conditions through oxidative stress, inflammation, and apoptosis. Because it is present in food, water, pharmaceuticals, and consumer products, chronic exposure is nearly unavoidable and poses a public health concern. Luteolin (LUT), a natural flavone with antioxidant, anti-inflammatory, and metal-chelating properties, has emerged as a potential neuroprotective agent. This study investigated the protective effects of LUT against aluminum chloride (AlCl

Indexed as

Aluminum ChlorideAntioxidantsBrain InjuriesChelating AgentsLuteolinNeuroprotective AgentsNeurotoxicity SyndromesAluminumAnimalsApoptosisBehavior, AnimalBrainMaleOxidative StressRatsRats, Sprague-DawleyAluminumAluminum ChlorideAntioxidantsChelating AgentsLuteolinNeuroprotective AgentsAluminumApoptosisInflammationLuteolinNeurodegenerationOxidative stress

Identifiers

PMID42201342
PMCPMC13503386

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.