Evidence map›Paper›PMID 42201462›Full record

ArticleNeurochemical research2026

Ethylmalonic and Methylsuccinic Acids Disrupt Bioenergetics and Induce Mitochondrial Permeability Transition Through Thiol Redox Modulation in Rat Striatum: Potential Mechanisms Involved in Ethylmalonic Encephalopathy.

Manuela Bianchin Marcuzzo, Ângela Beatris Zemniaçak, Jaqueline Santana da Rosa, Bianca Silveira Signorini Verdi, Maria Paula Dalla Vechia Benati, Josyane de Andrade Silveira, Juliana Gomes do Nascimento, Helena de Almeida Moreira, Mateus Dias-Oliveira, Diogo Onofre Souza and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurochemical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Manuela Bianchin MarcuzzoPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, 90035-003, RS, Brazil.
Ângela Beatris ZemniaçakPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, 90035-003, RS, Brazil.
Jaqueline Santana da RosaPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, 90035-003, RS, Brazil.
Bianca Silveira Signorini VerdiPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, 90035-003, RS, Brazil.
Maria Paula Dalla Vechia BenatiPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, 90035-003, RS, Brazil.
Josyane de Andrade SilveiraPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, 90035-003, RS, Brazil.
Juliana Gomes do NascimentoPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, 90035-003, RS, Brazil.
Helena de Almeida MoreiraPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, 90035-003, RS, Brazil.
Mateus Dias-OliveiraPostgraduate Programme in Cellular and Molecular Biology (PPGBCM), Center of Biotechnology, Federal University of Rio Grande do Sul, Porto Alegre, 90650-001, RS, Brazil.
Diogo Onofre SouzaPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, 90035-003, RS, Brazil.
Alexandre Umpierrez AmaralPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, 90035-003, RS, Brazil.
Geancarlo ZanattaPostgraduate Programme in Cellular and Molecular Biology (PPGBCM), Center of Biotechnology, Federal University of Rio Grande do Sul, Porto Alegre, 90650-001, RS, Brazil.
Moacir WajnerPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, 90035-003, RS, Brazil.
Guilhian LeipnitzPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, 90035-003, RS, Brazil. guilhian@ufrgs.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ethylmalonic (EMA) and methylsuccinic (MSA) acids concentrations are elevated in tissues and body fluids of patients with ethylmalonic encephalopathy (EE), a mitochondrial disorder associated with basal ganglia abnormalities. To clarify the pathophysiology of this disorder, we evaluated the effects of EMA and MSA on bioenergetics, redox homeostasis and mitochondrial permeability transition (MPT) in rat striatum. We verified that EMA and MSA reduced state 3 and uncoupled respiration and inhibited the activities of α-ketoglutarate dehydrogenase and complex IV of the electron transport chain. Both organic acids also decreased mitochondrial membrane potential and Ca

Indexed as

Brain Diseases, Metabolic, InbornCorpus StriatumEnergy MetabolismMalonatesMitochondriaPurpuraSulfhydryl CompoundsAnimalsMaleMembrane Potential, MitochondrialMitochondrial Permeability Transition PoreOxidation-ReductionRatsRats, Wistarethylmalonic acidMalonatesMitochondrial Permeability Transition PoreSulfhydryl CompoundsBioenergeticsEthylmalonic acidEthylmalonic encephalopathyMethylsuccinic acidMitochondrial permeability transitionStriatum

Identifiers

PMID42201462
PMCPMC13216122

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.