Evidence map›Paper›PMID 42201531›Full record

ArticleJournal of thrombosis and thrombolysis2026

Association between cerebrospinal fluid metabolites and ischemic stroke: a Mendelian randomization analysis.

Zhen Wei, Chunshu Rong, Qiyi Ta, Xu Wang, Dexi Zhao

Abstract read
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In one paragraph

Article in Journal of thrombosis and thrombolysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhen WeiMedical Intensive Care Unit, The Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, 130021, Jilin, China.
Chunshu RongDepartment of Encephalopathy, The Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, 130021, Jilin, China.
Qiyi TaCollege of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, 130117, Jilin, China.
Xu WangCollege of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, 130117, Jilin, China. 20202701164@stu.ccucm.edu.cn.
Dexi ZhaoCollege of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, 130117, Jilin, China. zdx02@163.com.

Funding

Jilin Province Science And Technology Development Plan Project (YDZJ202501ZYTS767)
6 · The paper itself

Abstract

Ischemic stroke (IS) is one of the leading causes of disability and mortality worldwide. Cerebrospinal fluid (CSF) metabolites can reflect the pathophysiological state of the central nervous system, but their causal relationship with IS remains unclear. This study aims to assess the causal association between CSF metabolites and IS prognosis using Mendelian randomization (MR) methodology. A two-sample MR design was employed, with genetic data on CSF metabolites sourced from the WADRC and WRAP cohorts (a total of 338 metabolites in a European ancestry population), and IS prognosis outcome data obtained from the GISCOME network (6021 IS patients). Single nucleotide polymorphisms (SNPs) significantly associated at P < 5 × 10

Indexed as

Cerebrospinal fluid metabolitesDeoxyuridineGenome-wide association studiesIschemic strokeMendelian randomization

Identifiers

PMID42201531

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.