WGCNA-Based Identification of HSPB1 Reveals a HOXA5/METTL1-m7G Regulatory Axis that Promotes Malignant Progression and Suppresses Ferroptosis in Glioblastoma.

Hongchao Li, Yusheng Chen, Yanyan Zhu, Shanbao Ke, Danting Wu

Abstract read

In one paragraph

Article in Neurochemical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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5 authors.

Hongchao LiDepartment of Neurosurgery, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Hospital of Henan University, Jinshui District, No. 7, Weiwu Road, Zhengzhou, 450003, Henan, China.

Yusheng ChenDepartment of Neurosurgery, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Hospital of Henan University, Jinshui District, No. 7, Weiwu Road, Zhengzhou, 450003, Henan, China. chenyusheng1983@126.com.

Yanyan ZhuDepartment of Oncology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Hospital of Henan University, Zhengzhou, 450003, Henan, China.

Shanbao KeDepartment of Oncology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Hospital of Henan University, Zhengzhou, 450003, Henan, China.

Danting WuDepartment of Pathology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Hospital of Henan University, Zhengzhou, 450003, Henan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma (GBM) is the most aggressive primary brain tumor with a dismal prognosis. Ferroptosis is implicated in GBM pathogenesis. Heat shock protein B1 (HSPB1) is associated with tumor progression, yet its precise function and regulatory mechanism in GBM ferroptosis remain elusive. Differentially expressed genes were identified from the GSE151352 dataset. WGCNA was employed to identify GBM-associated modules, which were then intersected with genes from the FerrDb V2 database. HSPB1 expression and prognostic value were validated using TCGA and GEPIA databases, and clinical specimens. Functional assays (EdU, TUNEL, and Transwell) and ferroptosis indicators (lipid ROS, Fe

Indexed as

Brain NeoplasmsFerroptosisGlioblastomaHeat-Shock ProteinsHomeodomain ProteinsHSP27 Heat-Shock ProteinsMethyltransferasesMolecular ChaperonesAnimalsCell Line, TumorDisease ProgressionGene Expression Regulation, NeoplasticHumansMiceMice, NudeHeat-Shock ProteinsHomeodomain ProteinsHSP27 Heat-Shock ProteinsHSPB1 protein, humanMethyltransferasesMolecular ChaperonesFerroptosisGlioblastomaHeat shock protein B1Homeobox A5Methyltransferase like 1N7-methylguanosine methylationWeighted gene co-expression network analysis

Identifiers

PMID42201601

DOI10.1016/j.canlet.2022.215605

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.