Evidence map›Paper›PMID 42201959›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

NF1 and SPRED1/2 cooperate through RAS-MAPK-independent functions.

Jillian M Silva, Lizzeth Canche, Alice Cheng, Lucy C Young, Frank McCormick

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jillian M SilvaHelen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94153.
Lizzeth CancheHelen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94153.
Alice ChengHelen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94153.
Lucy C YoungHelen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94153.ORCID 0000-0003-2703-2347
Frank McCormickHelen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94153.ORCID 0000-0002-6619-7120

Funding

New Ways of Targeting K-RasR35CA197709 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MCCORMICK, FRANK PATRICK · 2016 to 2022
$6.7M
Mechanisms of cooperation between MAPK and PI3K signaling in melanomaK01CA197138 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SILVA, JILLIAN · 2015 to 2020
$863k
NCI NIH HHS K01 CA197138NCI NIH HHS R35 CA197709
6 · The paper itself

Abstract

Neurofibromin, the protein product of the neurofibromatosis type 1 (

Indexed as

Adaptor Proteins, Signal TransducingNeurofibromin 1ras ProteinsAnimalsFibroblastsHumansMAP Kinase Signaling SystemMiceNeurofibromatosis 1Proto-Oncogene Proteins p21(ras)Repressor ProteinsSignal TransductionAdaptor Proteins, Signal TransducingNeurofibromin 1Proto-Oncogene Proteins p21(ras)ras ProteinsRepressor ProteinsSPRED1 protein, humanSpred1 protein, mouseSpred2 protein, mouseMAPKneurofibrominRASSPRED

Identifiers

PMID42201959
PMCPMC13229218

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.