Evidence map›Paper›PMID 42201999›Full record

ArticleScience advances2026

State-specific inhibition of NMDA receptors by memantine provides insight into NMDAR channel blocker tolerability.

Matthew B Phillips, Nadya V Povysheva, Elizabeth G Neureiter, Aparna Nigam, Karen A Harnett-Scott, Johannes W Hell, Elias Aizenman, Jon W Johnson

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Matthew B PhillipsDepartment of Neuroscience and Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-4360-7473
Nadya V PovyshevaDepartment of Neuroscience and Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-6842-8391
Elizabeth G NeureiterDepartment of Neuroscience and Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-4772-3164
Aparna NigamDepartment of Neuroscience and Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-7972-9464
Karen A Harnett-ScottDepartment of Neurobiology and the Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID 0009-0007-8078-7366
Johannes W HellDepartment of Pharmacology, University of California, Davis, CA, USA.ORCID 0000-0001-7960-7531
Elias AizenmanDepartment of Neurobiology and the Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID 0000-0001-9610-4194
Jon W JohnsonDepartment of Neuroscience and Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0001-5085-3296

Funding

Ca2+-Dependent Block by Mematine and Selective Inhibition of Overactive NMDA ReceptorsR01AG065594 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOHNSON, JON W. · 2020 to 2024
$2.8M
Channel Block and Gating of NMDA ReceptorsR01GM128195 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOHNSON, JON W. · 2019 to 2022
$1.6M
Structural determinants of Ca(2+)-dependent inhibition of NMDA receptors by memantineF31NS113477 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PHILLIPS, MATTHEW BRYAN · 2019 to 2020
$91k
NIA NIH HHS R01 AG065594NIGMS NIH HHS R01 GM128195NINDS NIH HHS F31 NS113477
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Excitatory Amino Acid AntagonistsMemantineReceptors, N-Methyl-D-AspartateAnimalsCalciumHEK293 CellsHumansKetamineNeuronsCalciumExcitatory Amino Acid AntagonistsKetamineMemantineReceptors, N-Methyl-D-Aspartate

Identifiers

PMID42201999
PMCPMC13215171

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.