Evidence map›Paper›PMID 42202008›Full record

ArticleScience advances2026

Multicellular senescence impairs skeletal muscle recovery following disuse in aging.

Paul-Emile Bourrant, Elena M Yee, Zachary J Fennel, Robert J Castro, Chad M Skiles, Jonathan J Petrocelli, Naomi M M P de Hart, Lisa A Lesniewski, Anna E Beaudin, Katsuhiko Funai and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Paul-Emile BourrantDepartment of Nutrition and Integrative Physiology, University of Utah, 250 South 1850 East, Salt Lake City, UT 84112, USA.ORCID 0009-0002-1047-5897
Elena M YeeDepartment of Nutrition and Integrative Physiology, University of Utah, 250 South 1850 East, Salt Lake City, UT 84112, USA.ORCID 0009-0002-5339-8051
Zachary J FennelDepartment of Physical Therapy and Athletic Training, University of Utah, 520 Wakara Way, Salt Lake City, UT 84108, USA.ORCID 0000-0001-9482-7815
Robert J CastroDepartment of Nutrition and Integrative Physiology, University of Utah, 250 South 1850 East, Salt Lake City, UT 84112, USA.ORCID 0000-0002-4025-0077
Chad M SkilesDepartment of Physical Therapy and Athletic Training, University of Utah, 520 Wakara Way, Salt Lake City, UT 84108, USA.ORCID 0009-0003-8618-5092
Jonathan J PetrocelliDepartment of Physical Therapy and Athletic Training, University of Utah, 520 Wakara Way, Salt Lake City, UT 84108, USA.ORCID 0000-0003-1298-4257
Naomi M M P de HartDepartment of Nutrition and Integrative Physiology, University of Utah, 250 South 1850 East, Salt Lake City, UT 84112, USA.ORCID 0009-0004-6732-0217
Lisa A LesniewskiDepartment of Internal Medicine, Division of Geriatrics, University of Utah, 30 North Mario Capecchi Dr, 2nd Floor North, Salt Lake City, Utah 84112, USA.
Anna E BeaudinDepartments of Pathology and Internal Medicine and Program in Molecular Medicine, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0002-8580-8660
Katsuhiko FunaiDepartment of Nutrition and Integrative Physiology, University of Utah, 250 South 1850 East, Salt Lake City, UT 84112, USA.ORCID 0000-0003-3802-4756
Christopher S FryCenter for Muscle Biology, University of Kentucky, Lexington, KY 40536-0200, USA.ORCID 0000-0002-4207-6594
Micah J DrummondDepartment of Nutrition and Integrative Physiology, University of Utah, 250 South 1850 East, Salt Lake City, UT 84112, USA.ORCID 0000-0001-5961-8890

Funding

Regulation of macrophage metabolism in aged muscle during recoveryR01AG076075 · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2025 to 2025
$657k
NIA NIH HHS R01 AG076075
6 · The paper itself

Abstract

Aged skeletal muscle has a diminished capacity to recover after disuse. Although muscle regrowth requires coordinated interactions between immune and progenitor cells, the mechanisms of impaired remodeling in aged skeletal muscle remain poorly understood yet possibly involve the accumulation of senescent cells. We used a flow cytometry approach coupled with scRNAseq to determine the muscle senescent cell identity and transcriptional landscape during skeletal muscle recovery following disuse atrophy. Young and aged mice underwent 14 days of hindlimb unloading followed by reloading (7 or 14 days). At recovery, old mice showed smaller myofibers and abnormal muscle macrophage dynamics corresponding to greater collagen content. These outcomes coincided with elevated markers of muscle senescence (p21 and γH2AX) and increased SPiDER-β-Gal

Indexed as

AgingCellular SenescenceMuscle, SkeletalMuscular Disorders, AtrophicAnimalsMacrophagesMaleMice

Identifiers

PMID42202008
PMCPMC13215201

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.