In one paragraphArticle in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
17 authors.
Samia HannaouiCalgary Prion Research Unit, Faculty of Veterinary Medicine, University of Calgary, 3280 Hospital Dr NW, T2N 4Z6 Calgary, Canada.ORCID 0009-0003-8122-9797 Sandra PritzkowMitchell Center for Alzheimer's Disease and related Brain Disorders, University of Texas McGovern Medical School at Houston, 6431 Fannin Street, Houston, TX 77030, USA.
Wiebke M Jürgens-WemheuerInstitute of Neuropathology, Faculty of Medicine, Saarland University, Homburg, Germany.ORCID 0000-0002-1234-3321 Dirk MotzkusGerman Primate Center (DPZ), Leibniz Institute for Primate Research. Unit of Infection Models, Kellnerweg 4, D-37077 Goettingen, Germany.
Joo-Hee WälzleinPrion and Prionoid Research Unit, ZBS 6-Proteomics and Spectroscopy, ZBS-Centre for Biological Threats and Special Pathogens, Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany.ORCID 0000-0002-8391-7724 Karla A SchwenkePrion and Prionoid Research Unit, ZBS 6-Proteomics and Spectroscopy, ZBS-Centre for Biological Threats and Special Pathogens, Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany.ORCID 0000-0002-6379-9951 Yo-Ching ChengCalgary Prion Research Unit, Faculty of Veterinary Medicine, University of Calgary, 3280 Hospital Dr NW, T2N 4Z6 Calgary, Canada.ORCID 0009-0006-6594-6309 Hanaa Ahmed HassanCalgary Prion Research Unit, Faculty of Veterinary Medicine, University of Calgary, 3280 Hospital Dr NW, T2N 4Z6 Calgary, Canada.
Irina ZemlyankinaCalgary Prion Research Unit, Faculty of Veterinary Medicine, University of Calgary, 3280 Hospital Dr NW, T2N 4Z6 Calgary, Canada.ORCID 0000-0002-6755-5380 Kylee DreverCalgary Prion Research Unit, Faculty of Veterinary Medicine, University of Calgary, 3280 Hospital Dr NW, T2N 4Z6 Calgary, Canada.ORCID 0000-0001-6391-609X Michael BeekesPrion and Prionoid Research Unit, ZBS 6-Proteomics and Spectroscopy, ZBS-Centre for Biological Threats and Special Pathogens, Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany.ORCID 0000-0002-6454-6657 Walter J Schulz-SchaefferInstitute of Neuropathology, Faculty of Medicine, Saarland University, Homburg, Germany.ORCID 0000-0001-5886-2322 Christiane Stahl-HennigGerman Primate Center (DPZ), Leibniz Institute for Primate Research. Unit of Infection Models, Kellnerweg 4, D-37077 Goettingen, Germany.ORCID 0000-0001-5545-8498 Sabine GilchCalgary Prion Research Unit, Faculty of Veterinary Medicine, University of Calgary, 3280 Hospital Dr NW, T2N 4Z6 Calgary, Canada.ORCID 0000-0001-5923-3464 Claudio SotoMitchell Center for Alzheimer's Disease and related Brain Disorders, University of Texas McGovern Medical School at Houston, 6431 Fannin Street, Houston, TX 77030, USA.ORCID 0000-0002-3412-0524 Stefanie CzubCalgary Prion Research Unit, Faculty of Veterinary Medicine, University of Calgary, 3280 Hospital Dr NW, T2N 4Z6 Calgary, Canada.ORCID 0009-0001-4165-2705 Hermann M SchätzlCalgary Prion Research Unit, Faculty of Veterinary Medicine, University of Calgary, 3280 Hospital Dr NW, T2N 4Z6 Calgary, Canada.ORCID 0000-0003-4972-8740 Funding
Redefining the zoonotic potential of chronic wasting diseaseR01NS121016 · NINDS · UNIVERSITY OF CALGARY · PI GILCH, SABINE, SCHATZL, HERMANN M · 2021 to 2025
$1.3MNINDS NIH HHS R01 NS121016
6 · The paper itselfAbstract
Chronic wasting disease (CWD) is an expanding prion disease of cervids. CWD prions persist in the environment, are shed in excreta, and accumulate in tissues of infected cervids, raising concerns about its zoonotic potential. Using cynomolgus macaques, we explored the zoonotic potential of CWD. Although most inoculated macaques remained asymptomatic, sensitive in vitro prion amplification assays revealed low levels of prions in macaque tissues. Inoculation of transgenic mice and bank voles with macaque tissues induced prion disease, achieving 100% transmission rates upon serial passage. One interpretation of these findings is that CWD prions retain infectivity across species and that primate infection may manifest atypically while still enabling transmission. Our results challenge earlier conclusions that minimize the zoonotic risk of CWD and underscore the need for continued surveillance.
Indexed as
PrionsWasting Disease, ChronicZoonosesAnimalsArvicolinaeDeerMacaca fascicularisMiceMice, TransgenicPrions
Identifiers
PMID42202024
PMCPMC13215175
What Socratic holds
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LicenceCC BY
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