Evidence map›Paper›PMID 42202035›Full record

ArticleScience advances2026

Phosphorylation remodels the mitotic centrosome matrix to generate bipartite γ-tubulin complex docking sites.

Midori Ohta, Orie Arakawa, Yajie Gu, Wanying Tian, Kevin D Corbett, Arshad Desai, Karen Oegema

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Midori OhtaOkinawa Institute of Science and Technology Graduate University, Okinawa, Japan.ORCID 0000-0001-8189-6846
Orie ArakawaOkinawa Institute of Science and Technology Graduate University, Okinawa, Japan.ORCID 0000-0002-7823-5913
Yajie GuDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-1514-1477
Wanying TianDepartment of Cell and Developmental Biology, School of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Kevin D CorbettDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-5854-2388
Arshad DesaiDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-5410-1830
Karen OegemaDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-8515-7514

Funding

Analysis of Centrosome DynamicsR01GM074207 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI OEGEMA, KAREN F · 2006 to 2025
$6.6M
NIGMS NIH HHS R01 GM074207
6 · The paper itself

Abstract

Mitotic centrosomes consist of centrioles surrounded by a proteinaceous matrix that docks and activates γ-tubulin complexes (γTuCs) to nucleate microtubules for spindle assembly. During mitotic entry, phosphorylation at centrosomes remodels CDK5 regulatory subunit associated protein 2 (CDK5RAP2) family matrix proteins to generate γTuC docking sites. We address the mechanism of this conversion using

Indexed as

Caenorhabditis elegans ProteinsCentrosomeMitosisTubulinAnimalsBinding SitesCaenorhabditis elegansCell Cycle ProteinsCentrosomal Associated ProteinsPhosphorylationPolo-Like Kinase 1Protein BindingProtein Serine-Threonine KinasesProto-Oncogene ProteinsSpindle ApparatusCaenorhabditis elegans ProteinsCell Cycle ProteinsCentrosomal Associated ProteinsPolo-Like Kinase 1Protein Serine-Threonine KinasesProto-Oncogene ProteinsSPD-5 protein, C elegansTubulin

Identifiers

PMID42202035
PMCPMC13215203

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.