Evidence map›Paper›PMID 42203886›Full record

ArticleCommunications biology2026

Non-invasive electrical stimulation restores corneal nerve density and sensory function in diabetic neuropathy via KCNN-dependent mechanism.

Menglu Yang, Anton Lennikov, Lu Huang, Farris ElZaridi, Ningyuan Xu, Kai Yuan, Amy Li, Grace Coyne, Wai Lydia Tai, Dong Feng Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Menglu YangSchepens Eye Research Institute, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA. mengluyangpku@gmail.com.ORCID 0000-0003-3264-7194
Anton LennikovSchepens Eye Research Institute, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Lu HuangSchepens Eye Research Institute, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Farris ElZaridiSchepens Eye Research Institute, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Ningyuan XuSchepens Eye Research Institute, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Kai YuanSchepens Eye Research Institute, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Amy LiSchepens Eye Research Institute, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Grace CoyneSchepens Eye Research Institute, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.ORCID 0009-0005-9586-3830
Wai Lydia TaiSchepens Eye Research Institute, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Dong Feng ChenSchepens Eye Research Institute, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA. dongfeng_chen@meei.harvard.edu.ORCID 0000-0001-6283-8843

Funding

VISION RESEARCHP30EY003790 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI Sunil K Chauhan · 1985 to 2026
$25.5M
Non-invasive Electrical Stimulation as a Therapy for Diabetic KeratopathyR56EY037692 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI YANG, MENGLU · 2025 to 2025
$896k
NEI NIH HHS P30 EY003790NEI NIH HHS R56 EY037692U.S. Department of Defense (United States Department of Defense) HT9425-23-1-1045U.S. Department of Defense (United States Department of Defense) HT9425-24-1-0788U.S. Department of Health & Human Services | NIH | National Eye Institute (NEI) R56EY037692
6 · The paper itself

Abstract

Diabetic neuropathy (DN) is the most common complication of diabetes mellitus (DM) and often involves the cornea, where progressive loss of nerve fibers contributes to impaired corneal sensitivity and wound healing defects. Current treatments are limited, underscoring the need for a regenerative therapy. Here we show that a non-invasive neural modulation therapy, transcutaneous electrical stimulation (ES), significantly restore the nerve density and sensory function in both streptozotocin-induced DM mice and in vitro isolated trigeminal ganglia (TG) neurons. Transcriptomics analysis of TGs from in vivo ES points to ion transport and Ca

Indexed as

CorneaDiabetic NeuropathiesIntermediate-Conductance Calcium-Activated Potassium ChannelsAnimalsDiabetes Mellitus, ExperimentalMaleMiceMice, Inbred C57BLNerve RegenerationTrigeminal GanglionIntermediate-Conductance Calcium-Activated Potassium Channels

Identifiers

PMID42203886
PMCPMC13351063

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.