Evidence map›Paper›PMID 42204128›Full record

ArticleNeurocritical care2026

Intracranial Pressure and Brain Tissue Oxygen Trajectories after Cardiac Arrest.

Laura Faiver, Patrick J Coppler, Cecelia R Ratay, Jonathan Tam, Lori A Shutter, Nicholas Case, Jonathan Elmer, Pittsburgh Post Cardiac Arrest Service Investigators

Abstract read
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In one paragraph

Article in Neurocritical care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Laura FaiverDepartment of Critical Care Medicine, School of Medicine, University of Pittsburgh, Iroquois Building, Suite 400A, 3600 Forbes Avenue, Pittsburgh, PA, 15213, USA. Faiverlk@upmc.edu.ORCID http://orcid.org/0000-0001-5454-4773
Patrick J CopplerDepartment of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Cecelia R RatayDepartment of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Jonathan TamDepartment of Critical Care Medicine, School of Medicine, University of Pittsburgh, Iroquois Building, Suite 400A, 3600 Forbes Avenue, Pittsburgh, PA, 15213, USA.
Lori A ShutterDepartment of Critical Care Medicine, School of Medicine, University of Pittsburgh, Iroquois Building, Suite 400A, 3600 Forbes Avenue, Pittsburgh, PA, 15213, USA.
Nicholas CaseDepartment of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Jonathan ElmerDepartment of Critical Care Medicine, School of Medicine, University of Pittsburgh, Iroquois Building, Suite 400A, 3600 Forbes Avenue, Pittsburgh, PA, 15213, USA.
Pittsburgh Post Cardiac Arrest Service Investigators

Funding

NRSA Training CoreTL1TR001858 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RADOMSKI, THOMAS, RUBIO, DORIS M · 2016 to 2025
$11.1M
Emergency Medicine Research Career Development Program in the Neurological Sciences (EMRCDP-NS)K12NS137516 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Opeolu M Adeoye, Clifton W. Callaway · 2024 to 2026
$7.9M
PREcision Care In Cardiac ArrEst - ICECAP (PRECICECAP)R01NS119825 · NINDS · STANFORD UNIVERSITY · PI ELMER, JONATHAN, HIRSCH, KAREN G · 2021 to 2025
$7.0M
Multidisciplinary Training in Critical Care Outcomes ResearchT32HL007820 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Timothy D Girard, Jeremy M Kahn · 1996 to 2026
$6.4M
Optimizing Recovery prediction after Cardiac Arrest (ORCA)R01NS124642 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jonathan Elmer · 2022 to 2026
$3.2M
NIH HHS K12NS137516NIH HHS R01NS119825NIH HHS R01NS124642NIH HHS T32HL007820NIH HHS TL1TR001858
6 · The paper itself

Abstract

backgroundBrain tissue hypoxia [brain tissue oxygen tension (PbtO

methodsWe conducted a single-center retrospective study of patients who survived until hospitalization after cardiac arrest and underwent invasive neuromonitoring. We used group-based trajectory modeling to identify distinct trajectories of PbtO

resultsWe included 43 patients who underwent invasive neuromonitoring. We identified three ICP trajectory groups. Group 1 was characterized by normal ICP throughout monitoring, while group 2 demonstrated High-normal ICP during the study period. Group 3 had initially normal ICP, which rapidly increased and remained pathologically elevated thereafter. All ICP trajectory groups had episodically abnormal ICP, PbtO

conclusionsWe identified distinct PbtO

Indexed as

BrainHeart ArrestHypoxia-Ischemia, BrainIntracranial HypertensionIntracranial PressureOxygenAdultAgedFemaleHumansMaleMiddle AgedNeurophysiological MonitoringRetrospective StudiesOxygenGroup-based trajectory modelingHypoxic–ischemic brain injuryPhenotypesSecondary brain injury

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.