Evidence map›Paper›PMID 42204350›Full record

ArticleNPJ digital medicine2026

A clinical neuroimaging platform for rapid, automated lesion detection and personalized post-stroke outcome prediction.

Michal Brzus, Joseph Griffis, Cavan J Riley, Joel Bruss, Carrie Shea, Hans J Johnson, Aaron D Boes

Abstract read
In one paragraph

Article in NPJ digital medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Michal Brzus *Department of Electrical and Computer Engineering, The University of Iowa, Iowa City, IA, USA.
Joseph Griffis *Department of Pediatrics, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA.
Cavan J RileyDepartment of Electrical and Computer Engineering, The University of Iowa, Iowa City, IA, USA.
Joel BrussDepartment of Pediatrics, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA.
Carrie SheaDepartment of Pediatrics, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA.
Hans J JohnsonDepartment of Electrical and Computer Engineering, The University of Iowa, Iowa City, IA, USA.
Aaron D BoesDepartment of Pediatrics, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA. aaron-boes@uiowa.edu.

Funding

Predicting Cognitive Outcomes from Stroke Based on Lesion LocationR01NS114405 · NINDS · UNIVERSITY OF IOWA · PI BOES, AARON D · 2020 to 2024
$2.1M
University of Iowa - Research 3T MRI Connectome UpgradeS10OD025025 · OD · UNIVERSITY OF IOWA · PI MAGNOTTA, VINCENT A · 2018 to 2018
$1.9M
Predicting Cognitive Outcomes from Stroke Using Lesion LocationR01NS142391 · NINDS · UNIVERSITY OF IOWA · PI Aaron D Boes · 2026 to 2026
$582k
NIH HHS S10 OD025025NINDS NIH HHS 1 R01 NS114405-02NINDS NIH HHS R01 NS114405NINDS NIH HHS R01 NS142391
6 · The paper itself

Abstract

Accurately predicting long-term outcomes after stroke remains a key challenge in personalized medicine. Here, we present a neuroimaging platform that forecasts individualized cognitive outcomes in patients with ischemic stroke using deep learning-based lesion segmentation and location-/network-based features. This novel, fully automated system is capable of processing raw DICOM MRI data from heterogeneous scanners and generating text-based, personalized outcome information. To demonstrate this pipeline, we trained cognitive outcome-prediction models using a large lesion cohort (N = 604) and applied them to an independent stroke cohort (N = 153). Multiple cognitive outcome predictions achieved reasonable accuracy, with 96% concordance with manual methods. A report generated by a large language model provides interpretable, patient-specific prognoses within ~3 min. This demonstrates the potential for imaging-informed prognostication to inform stroke care and guide rehabilitation strategies.

Identifiers

PMID42204350
PMCPMC13493867

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.